Somatic STAT5b gain-of-function mutations in early onset nonclonal eosinophilia, urticaria, dermatitis, and diarrhea

Autor:	Michelle Makiya, Sergio D. Rosenzweig, Maureen J. O'Sullivan, Chi Ma, Adam DeZure, Jennifer Stoddard, Joshua D. Milner, Alexandra F. Freeman, Julie E. Niemela, Amy D. Klion, Stefania Pittaluga, Sophie Hambleton, Brian Cauff, Mark Raffeld, Grainne M. O'Regan, Liqiang Xi, T. Ronan Leahy, Gary Kleiner
Rok vydání:	2017
Předmět:	0301 basic medicine Pathology medicine.medical_specialty Somatic cell business.industry Hypereosinophilic syndrome Immunology STAT5B Cell Biology Hematology medicine.disease Biochemistry Dermatology 03 medical and health sciences Diarrhea 030104 developmental biology Gain of function hemic and lymphatic diseases medicine Eosinophilia medicine.symptom Letter to Blood business Early onset
Zdroj:	Blood. 129:650-653
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood-2016-09-737817
Popis:	To the editor: Somatic, gain-of-function mutations in STAT3 and STAT5 have been described in leukemias and lymphomas[1][1][⇓][2][⇓][3][⇓][4][⇓][5]-[6][6] and, more recently, in CD3-CD4+ T cells from a patient with lymphocytic variant hypereosinophilic syndrome[7][7]; whereas germ line gain
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f62ef78bd6adb55e37f4cfb2dfb078f https://doi.org/10.1182/blood-2016-09-737817 Zobrazit plný text záznamu