Treatment of multifocal primary cutaneous b-cell lymphoma: a clinical follow-up study of 29 patients
| Autor: | M.L. Geerts, Marcel W. Bekkenk, E.M. Noordijk, Maarten H. Vermeer, Chris J.L.M. Meijer, Pieter C. van Voorst Vader, Freerk Heule, Willem A. van Vloten, Rein Willemze |
|---|---|
| Přispěvatelé: | Dermatology, Other departments |
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Lymphoma B-Cell Skin Neoplasms medicine.medical_treatment CBCL Disease BORRELIA-BURGDORFERI THERAPY CLASSIFICATION Neoplasms Multiple Primary PROPOSAL Antineoplastic Combined Chemotherapy Protocols Medicine Humans Cyclophosphamide Aged Aged 80 and over Chemotherapy business.industry ORIGIN Follow up studies Middle Aged medicine.disease Dermatology Combined Modality Therapy Lymphoma Surgery Anti-Bacterial Agents Radiation therapy Oncology Doxorubicin Vincristine Conventional PCI Primary cutaneous immunocytoma Prednisone Female Lymphoma Large B-Cell Diffuse business Algorithms SKIN Follow-Up Studies RADIOTHERAPY |
| Zdroj: | Journal of Clinical Oncology, 17(8), 2471-2478. American Society of Clinical Oncology Journal of Clinical Oncology, 17(8), 2471-2478. AMER SOC CLINICAL ONCOLOGY Journal of clinical oncology, 17(8), 2471-2478. American Society of Clinical Oncology |
| ISSN: | 0732-183X |
| Popis: | PURPOSE: Although patients with primary cutaneous B-cell lymphoma (CBCL) and localized skin lesions are generally treated with radiotherapy and have an excellent prognosis, the clinical behavior and optimal treatment of CBCL presenting with multifocal skin lesions are less well defined. In this study, we evaluated the clinical behavior of and results of treatment for multifocal CBCL in 29 patients, and we formulated therapeutic guidelines. PATIENTS AND METHODS: The study group included 16 patients with primary cutaneous follicular center-cell lymphoma (PCFCCL), eight with primary cutaneous immunocytoma (PCI), and five with primary cutaneous large B-cell lymphoma presenting on the legs (PCLBCL of the leg). RESULTS: Only one of the 24 patients with multifocal PCFCCL or PCI developed extracutaneous disease, and no patient died from lymphoma (median follow-up, 54 months). In patients with PCFCCL, treatment with either multiagent chemotherapy (nine patients) or radiotherapy directed toward all skin lesions (five patients) proved equally effective in terms of complete remission, relapse, and survival. In contrast, all five patients with PCLBCL of the leg developed extracutaneous disease, and four of the five died from systemic lymphoma, 8 to 36 months (median, 21 months) after diagnosis. CONCLUSION: The results of these preliminary studies suggest that patients with PCFCCL or PCI presenting with multifocal skin lesions have the same excellent prognosis that patients with localized PCFCCL or PCI have and that radiotherapy directed toward all skin lesions is as effective as multiagent chemotherapy. Patients with PCLBCL of the leg have a more unfavorable prognosis, particularly patients presenting with multifocal skin lesions. This last group should always be treated with multiagent chemotherapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|