Analysis of T and NK cell subsets in Sicilian population from young to supercentenarian: the role of age and gender
| Autor: | Farzin Farzaneh, Nahid Zareian, Stefano Aprile, Francesco Gervasi, Floriana Bonura, Mattia Emanuela Ligotti, Fanny Pojero, Anna Aiello, Calogero Caruso, Matteo Bulati, Giovanni M. Giammanco, Giuseppina Candore, Giulia Accardi |
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| Přispěvatelé: | Ligotti, Mattia Emanuela, Aiello, Anna, Accardi, Giulia, Aprile, Stefano, Bonura, Floriana, Bulati, Matteo, Gervasi, Francesco, Giammanco, Giovanni M, Pojero, Fanny, Zareian, Nahid, Caruso, Calogero, Farzaneh, Farzin, Candore, Giuseppina |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
CD4-Positive T-Lymphocytes Male Aging Cytomegalovirus CD8-Positive T-Lymphocytes Supercentenarian 0302 clinical medicine Immunophenotyping T-Lymphocyte Subsets Immunology and Allergy Sicily Aged 80 and over education.field_of_study T lymphocyte subsets Age Factors CMV Gender Identity Middle Aged Immunity and Ageing Killer Cells Natural medicine.anatomical_structure Cytomegalovirus Infections Original Article Female Adult Naive T cell T cell Immunology Population CD4-CD8 Ratio Biology 03 medical and health sciences Immune system medicine Humans education Aged Settore MED/04 - Patologia Generale Cancer Gender medicine.disease T Lymphocyte subset 030104 developmental biology Ageing ORIGINAL ARTICLES CD8 030215 immunology |
| Zdroj: | Clinical and Experimental Immunology |
| Popis: | Summary Ageing dramatically affects number and function of both innate and adaptive arms of immune system, particularly T cell subsets, contributing to reduced vaccination efficacy, decreased resistance to infections and increased prevalence of cancer in older people. In the present paper, we analysed the age‐related changes in the absolute number of lymphocytes in 214 Sicilian subjects, and in the percentages of T and natural killer (NK) cells in a subcohort of donors. We compared these results with the immunophenotype of the oldest living Italian supercentenarian (aged 111 years). The results were also sorted by gender. The correlation between number/percentage of cells and age in all individuals. and separately in males and females, was examined using a simple linear regression analysis. We did not record the increase in the rate of inversion of the CD4/CD8 ratio, frequently reported as being associated with ageing in literature. Our observation was the direct consequence of a flat average trend of CD4+ and CD8+ T cell percentages in ageing donors, even when gender differences were included. Our results also suggest that CD4+ and CD8+ subsets are not affected equally by age comparing females with males, and we speculated that gender may affect the response to cytomegalovirus (CMV) infection. The supercentenarian showed a unique immunophenotypic signature regarding the relative percentages of her T cell subsets, with CD4+ and CD8+ T cell percentages and CD4+ naive T cell values in line with those recorded for the octogenarian subjects. This suggests that the supercentenarian has a naive ‘younger’ T cell profile comparable to that of a >80‐year‐old female. We investigated age‐related changes in the absolute number of lymphocytes among 216 Sicilian subjects (age range 22‐111) and in the percentages of circulating lymphocyte subsets in a smaller group of donors of different ages. The data were also analyzed by gender. The supercentenarian has a naïve ‘younger’ T cell profile comparable to that of an older female. |
| Databáze: | OpenAIRE |
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