Leakey Virus: a New Hantavirus Isolated from Mus musculus in the United States
| Autor: | M. Miyazaki, L. J. Baek, C. J. Gibbs, Gajdusek Dc, Richard Yanagihara |
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| Rok vydání: | 1988 |
| Předmět: |
Serotype
Orthohantavirus viruses Fluorescent Antibody Technique Spleen Biology Antibodies Viral Virus Neutralization Mice Meningoencephalitis Virology medicine Animals Serotyping Cells Cultured Hantaan virus Hantavirus virus diseases medicine.disease biology.organism_classification Texas Rats medicine.anatomical_structure Bunyaviridae |
| Zdroj: | Journal of General Virology. 69:3129-3132 |
| ISSN: | 1465-2099 0022-1317 |
| DOI: | 10.1099/0022-1317-69-12-3129 |
| Popis: | Summary A hantavirus, designated Leakey virus, was isolated from a Mus musculus captured in Real County, Texas, U.S.A. in August 1986. Virus-specific fluorescence was first detected 13 days after inoculation of Vero-E6 cells with spleen tissue from the seropositive M. musculus. Ultrastructurally, the new isolate resembled other hantaviruses. Leakey virus induced a fatal meningoencephalitis in infant Fischer rats, with viral antigen detectable in brain, lung, liver, kidney and spleen. Serum dilution, plaque reduction neutralization tests indicated that Leakey virus was antigenically distinct from Hantaan, Seoul, Puumala and Prospect Hill viruses, and therefore constitutes a new serotype. |
| Databáze: | OpenAIRE |
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