Reactive Carbonyl SpeciesIn Vivo: Generation and Dual Biological Effects
| Autor: | Semchyshyn Hm |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Transcription
Genetic Cell lcsh:Medicine Review Article macromolecular substances Biology lcsh:Technology General Biochemistry Genetics and Molecular Biology In vivo medicine lcsh:Science Cytotoxicity General Environmental Science chemistry.chemical_classification lcsh:T Biomolecule lcsh:R General Medicine Metabolism Ketones Amino acid medicine.anatomical_structure Biochemistry chemistry Nucleic acid lcsh:Q Signal transduction Signal Transduction |
| Zdroj: | The Scientific World Journal, Vol 2014 (2014) The Scientific World Journal |
| ISSN: | 1537-744X 2356-6140 |
| DOI: | 10.1155/2014/417842 |
| Popis: | Reactive carbonyls are widespread species in living organisms and mainly known for their damaging effects. The most abundant reactive carbonyl species (RCS) are derived from oxidation of carbohydrates, lipids, and amino acids. Chemical modification of proteins, nucleic acids, and aminophospholipids by RCS results in cytotoxicity and mutagenicity. In addition to their direct toxicity, modification of biomolecules by RCS gives rise to a multitude of adducts and cross links that are increasingly implicated in aging and pathology of a wide range of human diseases. Understanding of the relationship between metabolism of RCS and the development of pathological disorders and diseases may help to develop effective approaches to prevent a number of disorders and diseases. On the other hand, constant persistence of RCS in cells suggests that they perform some useful role in living organisms. The most beneficial effects of RCS are their establishment as regulators of cell signal transduction and gene expression. Since RCS can modulate different biological processes, new tools are required to decipher the precise mechanisms underlying dual effects of RCS. |
| Databáze: | OpenAIRE |
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