Human leukocyte antigen class I polymorphisms influence the mild clinical manifestation of Plasmodium falciparum infection in Ghanaian children
| Autor: | Kenji Hirayama, Kazunari Ishii, Gideon Kofi Helegbe, Akiko Yamazaki, Bartholomew D. Akanmori, Akiko Takaki, Hitomi Horie, Mihoko Kikuchi, Michael F. Ofori, Ahmeddin H Omar, Michio Yasunami |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Genotype Immunology Plasmodium falciparum Black People Human leukocyte antigen Parasitemia Biology Parasite load Ghana Severity of Illness Index Parasite Load Gene Frequency parasitic diseases medicine Genetic predisposition Leukocytes Immunology and Allergy Humans Prospective Studies Allele Malaria Falciparum Prospective cohort study Child Alleles Genetic Association Studies Polymorphism Genetic HLA-A Antigens Tumor Necrosis Factor-alpha Histocompatibility Testing Incidence General Medicine medicine.disease Phenotype HLA-B Antigens Relative risk Child Preschool Female Disease Susceptibility Malaria HLA-DRB1 Chains |
| Zdroj: | Human immunology. 72(10) |
| ISSN: | 1879-1166 |
| Popis: | A prospective study that included 429 children for active detection of mild malaria was conducted in a coastal region of Ghana to reveal whether the incidence of malaria is affected by human leukocyte antigen (HLA) polymorphism. During 12 months of follow-up, 85 episodes of mild clinical malaria in 74 individuals were observed, and 34 episodes among them were accompanied with significant parasitemia at >5000 infected red blood cells per cubic millimeter. Attributable and relative risks conferred by genetic factors in the HLA region were evaluated by comparison of the incidence in children, stratified by carrier status, of a given allele of HLA-A, -B, -DRB1 and TNFA promoter polymorphism. HLA-B*35:01 reduced the incidence by 0.178 events per person per year (0.060 versus 0.239 for B*35:01-positive and -negative subpopulations, respectively), and a relative risk of 0.25, which remained statistically significant after Bonferroni's correction for multiple testing ( p c = 8.2 × 10 −5 ). Further, HLA-B*35:01 and -B*53:01 exhibited opposite effects on the incidence of malaria with significant parasitemia. When parasite densities in different HLA carriers status were compared, HLA-A*01 conferred an increase in parasite load ( p = 6.0 × 10 −7 ). In addition, we found a novel DRB1 allele that appears to have emerged from DRB1*03:02 by single nucleotide substitution. |
| Databáze: | OpenAIRE |
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