Toward a new strategy in desmoid of the breast?
| Autor: | Françoise Rimareix, P. Terrier, A. Le Cesne, Olivier Mir, Chafika Mazouni, Julien Domont, Charles Honoré, S. Bonvalot, C. Le Pechoux, S. Roussin |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Breast surgery Patient characteristics Breast Neoplasms Breast Neoplasms Male Young Adult medicine Humans In patient Breast Watchful Waiting Mastectomy Aged Tumor size Radiotherapy business.industry General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Surgery Tumor Burden Radiation therapy Fibromatosis Aggressive medicine.anatomical_structure Oncology Aggressive fibromatosis Disease Progression Female Neoplasm Recurrence Local business Thoracic wall Follow-Up Studies |
| Zdroj: | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 41(4) |
| ISSN: | 1532-2157 |
| Popis: | Aim To report initial results of observation as well as surgery in patients with desmoid tumors (DTs) of the breast, a rare tumor for which data are scarce. Patients and methods The initial approaches were categorized as either front-line loco-regional treatment [(surgery or radiotherapy group, SRG) n = 20] or initial observation [(no surgery/no radiotherapy group, NSRG) n = 11]. Results A total of 27 women and 4 men were assessed between 1992 and 2013 and included in this study. Patient characteristics were adequately balanced in the 2 groups. Fifteen patients (48.4%) had a past history of breast surgery in the previous 24 months. The median initial DT size on MRI was 50 mm. The median follow-up was 36 months. In the SRG, 8/20 patients (40%) experienced recurrence. The median time to recurrence was 29 months. During the study period, 6 patients in the SRG (30%) received a mastectomy at the time of diagnosis (n = 3) or at relapse (n = 3), 7 patients (35%) received a thoracic wall resection and 8 patients (40%) received radiotherapy at the time of diagnosis (n = 2) or at recurrence (n = 5). In the NSRG, the median tumor size change was −4 mm (range −13 to +20). Three patients changed treatment strategies during the observation period; one received surgery, and 2 were administered anti-hormonal treatment. Conclusions Loco-regional treatments of breast DTs resulted in undesired disfigurement. Front-line observation yielded encouraging results and could enable the identification of patients who require loco-regional treatment. This strategy needs further evaluation. |
| Databáze: | OpenAIRE |
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