Minimally invasive surgery using intraoperative electron-beam radiotherapy for the treatment of soft tissue sarcoma of the extremities with tendon involvement
| Autor: | Kunihiro Asanuma, Tomoki Nakamura, Akihiko Matsumine, Masaya Tsujii, Takao Matsubara, Akihiro Sudo, Akinori Takada, Takuya Kakimoto, Yoshihito Nomoto, Noriko, Yuki Yada |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.medical_treatment Pilot Projects 030230 surgery Tendons Young Adult 03 medical and health sciences 0302 clinical medicine Electron beam radiotherapy Minimally invasive surgery Surgical oncology medicine Humans Minimally Invasive Surgical Procedures Neoplasm Invasiveness Tendon involvement Soft tissue sarcoma Clinical outcome business.industry Research Standard treatment Extremities Sarcoma Middle Aged medicine.disease Tendon Surgery Radiation therapy Treatment Outcome medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Invasive surgery Female Radiotherapy Adjuvant Intraoperative electron-beam radiotherapy (IOERT) business Follow-Up Studies |
| Zdroj: | World Journal of Surgical Oncology |
| ISSN: | 1477-7819 |
| DOI: | 10.1186/s12957-016-0968-4 |
| Popis: | Background When a soft tissue sarcoma (STS) is located at the distal part of an extremity and involves the tendon, a wide excision usually causes severe functional disability. We therefore developed a minimally invasive surgical technique using intraoperative electron-beam radiotherapy (IOERT) to reduce the incidence of post-operative functional disability in patients with peri-/intra-tendinous STS. We assessed the clinical outcomes of the novel minimally invasive surgery. Methods The study population included five patients who received treatment for distal extremity STSs. After elevating the tumor mass, including the tendon and nerve from the tumor bed with a wide margin, a lead board was inserted beneath the tumor mass to shield the normal tissue. IOERT (25–50 Gy) was then applied, and the tumor excised with care taken to maintain the continuity of the tendon. Results In a desmoid patient, local recurrence was observed outside the irradiated field. No cases of neuropathy or bone necrosis were observed. The mean limb function score was excellent in all patients. None of the high-grade sarcoma patients had local recurrence or distant metastasis. Conclusions Although the current study is only a pilot study with a small number of patients, it shows that this minimally invasive procedure has the potential to become a standard treatment option for selected patients. Trial registration H17-250 (registered 2 November 2005) and H25-250 (modified from H17-250, registered 5 December 2013) |
| Databáze: | OpenAIRE |
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