HDL concentration, lipid transfer to HDL, and HDL size in normolipidemic nonobese menopausal women
| Autor: | Raul C. Maranhão, Nilson Roberto de Melo, Aricia Helena Galvão Giribela, Maria C. Latrilha, E.C. Baracat |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class chemistry.chemical_compound Internal medicine medicine Humans biology Triglyceride Cholesterol business.industry nutritional and metabolic diseases Obstetrics and Gynecology General Medicine Serum concentration Middle Aged medicine.disease Lipid Metabolism Laser light scattering Menopause Molecular Weight Cholesterol plasma Endocrinology Cross-Sectional Studies chemistry Estrogen biology.protein lipids (amino acids peptides and proteins) Apolipoprotein A1 Female business Lipoproteins HDL |
| Zdroj: | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 104(2) |
| ISSN: | 0020-7292 |
| Popis: | Objective To determine the impact of menopause on lipid transfer from donor lipoproteins to high-density lipoproteins (HDLs)—a process that is related to the protective function of HDL—and the size of HDL particles. Method Plasma from 22 premenopausal and 18 postmenopausal nonobese, normolipidemic women paired for age (40–50 years) was incubated in an artificial nanoemulsion labeled with radioactive lipids. Then the HDL fraction was assessed for radioactivity; the percentage of radioactive lipids transferred from the nanoemulsion to HDL was determined; and the size of HDL particles was measured by laser light scattering. Results There were no differences between the 2 groups in serum concentration of HDL cholesterol (61 ± 12 mg/dL vs 61 ± 14 mg/dL) or apolipoprotein A1 (1.5 ± 0.3 g/L vs 1.5 ± 0.2 g/L); lipid transfer to HDL; or size of HDL particles (8.8 ± 0.8 vs 9.0 ± 0.5 nm). Conclusion Menopause was not found to affect HDL cholesterol plasma concentration, lipid transfer to HDL, or size of HDL particles in normolipidemic nonobese women. |
| Databáze: | OpenAIRE |
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