Is C-11 Methionine PET an alternative to 18-F FDG-PET for identifying recurrent laryngeal cancer after radiotherapy?

Autor: Lisa van der Putten, Jan Wedman, Otto S. Hoekstra, Jan Pruim, Remco de Bree, Boukje A. C. van Dijk, Bernard F. A. M. van der Laan
Přispěvatelé: Guided Treatment in Optimal Selected Cancer Patients (GUTS), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Man, Biomaterials and Microbes (MBM), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), VU University medical center, Radiology and nuclear medicine, CCA - Imaging and biomarkers, Otolaryngology / Head & Neck Surgery, ACS - Heart failure & arrhythmias
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Clinical Otolaryngology, 44(2), 124. Wiley-Blackwell
Clinical Otolaryngology
Wedman, J, Pruim, J, van der Putten, L, Hoekstra, O S, de Bree, R, van Dijk, B A C & van der Laan, B F A M 2019, ' Is C-11 Methionine PET an alternative to 18-F FDG-PET for identifying recurrent laryngeal cancer after radiotherapy? ', Clinical Otolaryngology, vol. 44, no. 2, pp. 124-130 . https://doi.org/10.1111/coa.13242
Clinical Otolaryngology, 44(2), 124-130. Wiley
Clinical Otolaryngology, 44(2), 124-130. Blackwell Publishing Ltd Oxford, UK
ISSN: 0307-7772
1749-4478
Popis: Objective 18F FDG-PET is superior to other imaging techniques in revealing residual laryngeal cancer after radiotherapy. Unfortunately, its specificity is low, due to FDG uptake in inflammation and in anaerobic conditions. PET imaging with the amino acid-based radiopharmaceutical C11-methionine (MET) should be less influenced by post-radiation conditions. The aim of this study was to investigate the potential of MET in diagnosing recurrent laryngeal cancer after radiotherapy as compared to 18F-FDG. Methods Forty-eight patients with a clinical suspicion of local residual disease at least 3 months after completion of radiotherapy or chemoradiotherapy for a T2-4 laryngeal carcinoma, along with an indication for direct laryngoscopy, were included. They received MET-PET and FDG-PET prior to the direct laryngoscopy. One senior nuclear medicine physician assessed both the FDG-PET and MET-PET images visually for the degree of abnormal uptake. The gold standard was a biopsy-proven recurrence 12 months after PET. The nuclear physician had no access to the medical charts and was blinded to the results of the other PET. Sensitivity, specificity and positive and negative predictive value were calculated. Results The sensitivity of FDG was 77.3% and the specificity 56.0% after the conservative reading, with these values equalling 54.5% and 76.0% for MET. The positive predictive value of FDG was 60.7% and the negative predictive value 73.7%. The PPV of MET was 66.7%, and the NPV was 65.5%. The McNemar test within diseased (sensitivity comparison) shows a p-value of 0.125, and the McNemar test within non-diseased (specificity comparison) shows a P-value of 0.180. Conclusion MET-PET is not superior to FDG-PET in terms of identifying recurrent laryngeal cancer.
Databáze: OpenAIRE
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