Dual‐Input Regulation and Positional Control in Hybrid Oligonucleotide/Discotic Supramolecular Wires
| Autor: | Eva Magdalena Estirado, Lech-Gustav Milroy, Luc Brunsveld, Miguel Ángel Alemán García |
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| Přispěvatelé: | Chemical Biology |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Materials science
Base pair Macromolecular Substances Supramolecular chemistry Oligonucleotides Nanotechnology Macromolecular Substances/chemistry Conjugated system 010402 general chemistry 01 natural sciences Catalysis Supramolecular Chemistry Molecule Oligonucleotides/chemistry DNA/chemistry polymers chemistry.chemical_classification Molecular Structure Oligonucleotide 010405 organic chemistry Communication General Chemistry Polymer General Medicine DNA self-assembly hybrid systems Communications 0104 chemical sciences chemistry Hybrid system Self-assembly |
| Zdroj: | Angewandte Chemie (International Ed. in English) Angewandte Chemie-International Edition, 57(18), 4976-4980. Wiley Angewandte Chemie International Edition |
| ISSN: | 1521-3773 1433-7851 |
| Popis: | The combination of oligonucleotides and synthetic supramolecular systems allows for novel and long‐needed modes of regulation of the self‐assembly of both molecular elements. Discotic molecules were conjugated with short oligonucleotides and their assembly into responsive supramolecular wires studied. The self‐assembly of the discotic molecules provides additional stability for DNA‐duplex formation owing to a cooperative effect. The appended oligonucleotides allow for positional control of the discotic elements within the supramolecular wire. The programmed assembly of these hybrid architectures can be modulated through the DNA, for example, by changing the number of base pairs or salt concentration, and through the discotic platform by the addition of discotic elements without oligonucleotide handles. These hybrid supramolecular‐DNA structures allow for advanced levels of control over 1D dynamic platforms with responsive regulatory elements at the interface with biological systems. |
| Databáze: | OpenAIRE |
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