Is sonic hedgehog expression in saliva related to taste sensitivity in adults?
| Autor: | Elif Esra Ozturk, Derya Dikmen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Saliva Taste animal structures Experimental and Cognitive Psychology Umami Biology Body Mass Index 03 medical and health sciences Behavioral Neuroscience Young Adult 0302 clinical medicine stomatognathic system Internal medicine Taste bud Expression analysis medicine Humans 0501 psychology and cognitive sciences Taste Threshold Hedgehog Proteins 050102 behavioral science & comparative psychology Sonic hedgehog 05 social sciences Taste Perception Taste Buds medicine.anatomical_structure Endocrinology embryonic structures biology.protein Female Body mass index 030217 neurology & neurosurgery |
| Zdroj: | Physiologybehavior. 236 |
| ISSN: | 1873-507X |
| Popis: | Recent studies have demonstrated the critical role of the sonic hedgehog in the sensory perception of taste. Salivary sonic hedgehog stimulates taste bud stem cells, also acts as a taste bud growth factor, and contributes to the receptors' development and longevity in the taste buds. This study's objective was to investigate the possible relationship between taste sensitivity and sonic hedgehog expression in saliva in normal-weight and pre-obese/obese participants (totally 46 male (47.8%) and female (52.2%) aged 19-44 were recruited). Thresholds for the six tastes (sweet, salty, bitter, sour, umami and fat) were investigated using 3-Alternate Forced Choice Methodology. Saliva was collected with the draining method for sonic hedgehog expression analysis. The results indicated significantly higher thresholds for sweet, bitter and fat in pre-obese /obese adults than normal-weight adults (p0.05). The sonic hedgehog expression was also lower in pre-obese /obese participants than normal-weight participants (p0.05). Furthermore, sonic hedgehog expression was higher in hypersensitive participants than hyposensitive participants (p0.05) only among normal-weight individuals, with no significant difference in sonic hedgehog expression level by taste sensitivity in pre-obese/obese individuals (p0.05). Sonic hedgehog expression level was negatively correlated with body mass index, sweet, salty, bitter and fat taste threshold. The study results indicated that sonic hedgehog expression level acted on taste sensitivity in normal-weight participants, with greater expression in hypersensitive individuals than hyposensitive individuals. |
| Databáze: | OpenAIRE |
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