A Strain Difference in the Adrenal Zona Glomerulosa Determined by One Gene-Locus
| Autor: | J. G. M. Shire |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Male
medicine.medical_specialty Sodium H&E stain chemistry.chemical_element Biology Mice Endocrinology Species Specificity Internal medicine Adrenal Glands Genetic variation medicine Animals Allele Aldosterone Gene Genes Dominant Analysis of Variance Histocytochemistry Hydroxysteroid Dehydrogenases Diet Sodium-Restricted Water-Electrolyte Balance Glomerular Hypertrophy medicine.anatomical_structure chemistry Zona glomerulosa Backcrossing Hybridization Genetic Female |
| Zdroj: | Endocrinology. 85:415-422 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-85-3-415 |
| Popis: | The zona glomerulosa is well developed in the adrenal glands of CBA/FaCam mice and poorly developed in those of Peru mice. Measurements were made of the width of the subcapsular zone in hematoxylin and eosin stained paraffin sections of the adrenals of young adult malemice from these 2 strains, their F1, and the backcrosses to the parental strains.The pattern of results found in these stocks implies that the major portion of the strain difference is controlled by genetic variation at a single locus. The results of progeny tests of individual backcross backcross mice are in agreement with this hypothesis. It is suggested that the dominant allele found in CBA mice be called Ezg and that found in Peru mice, ezg. Sodium deficiency results in glomerular hypertrophy in CBA mice but not inPeru mice, even though urinary sodium measurements implied that both kinds of mice could effectively conserve sodium. The relationship between the difference in the zona glomerulosa and known differences in the metabolism of el... |
| Databáze: | OpenAIRE |
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