| Autor: |
Dixon, Michael L., Luo, Lin, Ghosh, Sadashib, Grimes, Jeffrey M., Leavenworth, Jonathan D., Leavenworth, Jianmei W. |
| Rok vydání: |
2021 |
| Předmět: |
|
| DOI: |
10.6084/m9.figshare.17054641 |
| Popis: |
Additional file 6: TIL effector cells and expression of effector molecules in TIL or splenic effector cells and Treg cells. B16-OVA/NP-OVA model was established in Foxp3YFP-Cre (WT) and Prdm1fl/flFoxp3YFP-Cre (KO) mice, as in Fig. 2c. a) Frequency of TIL immune cells (n = 7 per group, except n = 3 (WT) and n = 4 (KO) for F4/80+ cells). b-c) Frequency of each effector subset in spleens (WT: n = 8; KO: n = 6) (b) or tumors (n = 7 per group) (c) expressing IFN��, TNF�� and GzmB. d) Analysis and frequency of splenic Treg cells expressing IFN��, TNF�� and GzmB (WT: n = 8; KO: n = 6). ns, no significance, *** P < 0.001 and **** P < 0.0001 (a-d, unpaired two-tailed Student���s t-test). Bars, mean �� SEM. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
