Chemokine/Chemokine Receptor Indications in extramedullary leukaemia of the skin in childhood AML: differential roles for CCR2, CCR5, CXCR4 and CXCR7
| Autor: | R. Maarten Egeler, Maarten J. D. van Tol, T Revesz, Claudia M.J.M. Faaij, Astrid G. S. van Halteren, Elisabeth R. van Wering, Christian M. Zwaan, Melania Balzarolo, Annemieke Willemze, Cornelis P. Tensen, Gertjan J.L. Kaspers, Maarten H. Vermeer, Nicola E. Annels, Jaak M. Vossen, Colin Story, Manja Hoogeboom |
|---|---|
| Přispěvatelé: | Immunology, Pediatrics, Pediatric surgery, CCA - Innovative therapy |
| Rok vydání: | 2010 |
| Předmět: |
Male
CCR2 Chemokine Receptors CXCR4 Myeloid Skin Neoplasms Adolescent Receptors CCR5 Receptors CCR2 CX3C Chemokine Receptor 1 CXCR4 Chemokine receptor Leukemic Infiltration hemic and lymphatic diseases CX3CR1 AML chemokines paediatric haematology/oncology acute myelogenous leukemia acute myeloid-leukemia chemokine receptor lymphoblastic-leukemia cells expression survival infiltration diagnosis children medicine Humans Child neoplasms Skin Receptors CXCR biology integumentary system business.industry Infant Newborn Infant Hematology medicine.disease Leukemia Leukemia Myeloid Acute medicine.anatomical_structure Oncology Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health Immunology biology.protein Female Receptors Chemokine Bone marrow Chemokines business |
| Zdroj: | Pediatric Blood & Cancer, 55, 344-348. Wiley-Liss Inc. Pediatric Blood & Cancer, 55(2), 344-348 Pediatric Blood and Cancer, 55(2), 344-348. Wiley-Liss Inc. Pediatric Blood & Cancer Faaij, C M J M, Willemze, A J, Revesz, T, Balzarolo, M, Tensen, C P, Hoogeboom, M, Vermeer, M H, van Wering, E R, Zwaan, C M, Story, C, van Halteren, A G S, Kaspers, G J L, Vossen, J M, Egeler, R M, van Tol, M J D & Annels, N E 2010, ' Chemokine/Chemokine Receptor Interactions in Extramedullary Leukaemia of the Skin in Childhood AML: Differential Roles for CCR2, CCR5, CXCR4 and CXCR7 ', Pediatric Blood and Cancer, vol. 55, no. 2, pp. 344-348 . https://doi.org/10.1002/pbc.22500 |
| ISSN: | 1545-5009 |
| DOI: | 10.1002/pbc.22500 |
| Popis: | Chemokine receptor/ligand interactions orchestrate the migration of cells to peripheral tissues such as the skin. We analysed chemokine receptor expression by acute myeloid leukaemic (AML) cells present in peripheral blood (n = 7), bone marrow (n = 6), or skin (n = 11) obtained from 15 paediatric AML patients with skin involvement and in 10 AML patients without skin involvement. High percentages of circulating CCR2(pos) AML cells were only detected in patients with extramedullary disease. Skin-residing AML cells displayed a different set of receptors in situ, namely: CCR5, CXCR4, CXCR7 and CX3CR1. These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin. Pediatr Blood Cancer 2010;55:344-348. (C) 2010 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text