Antioxidants other than vitamin c may be detected by glucose meters: immediate relevance for patients with disorders targeted by antioxidant therapies
| Autor: | Patrice Maboudou, Raphaël Decoin, Pauline Vergriete, Thierry Brousseau, Joseph Vamecq, Pascal Odou, Marie Joncquel Chevalier-Curt, Jean-David Pekar, Guillaume Grzych, Héloïse Henry |
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| Přispěvatelé: | Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires (RNMCD - U1011), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 (GRITA), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 (RADEME), The authors thank the University Hospital (CHU) of Lille for supporting the present study., Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille, Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 (RNMCD), Université de Lille, LillOA |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
030213 general clinical medicine Antioxidant medicine.medical_treatment Point-of-Care Systems [SDV]Life Sciences [q-bio] Clinical Biochemistry Vitamin-C Ascorbic Acid 030204 cardiovascular system & hematology Pharmacology Antioxidants 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Glycemic control Diabetes mellitus medicine Falsely-elevated glycemia Humans Cysteine Glycemic Dihydrolipoate Vitamin C business.industry Glucose meter Blood Glucose Self-Monitoring Glucose Measurement COVID-19 General Medicine Glutathione medicine.disease Glycemic mismanagement Hypoglycemic drug overdoses N-acetylcysteine 3. Good health Acetylcysteine [SDV] Life Sciences [q-bio] Points-of-care Dithiothreitol chemistry Metabolic syndrome business |
| Zdroj: | Clinical biochemistry Clinical biochemistry, 2021, Clinical biochemistry, 92, pp.71-76. ⟨10.1016/j.clinbiochem.2021.03.007⟩ |
| ISSN: | 1873-2933 |
| Popis: | International audience; Owing to their ease of use, glucose meters are frequently used in research and medicine. However, little is known of whether other non-glucose molecules, besides vitamin C, interfere with glucometry. Therefore, we sought to determine whether other antioxidants might behave like vitamin C in causing falsely elevated blood glucose levels, potentially exposing patients to glycemic mismanagement by being administered harmful doses of glucose-lowering drugs. To determine whether various antioxidants can be detected by seven commercial glucose meters, human blood samples were spiked with various antioxidants ex vivo and their effect on the glucose results were assessed by Parkes error grid analysis. Several of the glucose meters demonstrated a positive bias in the glucose measurement of blood samples spiked with vitamin C, N-acetylcysteine, and glutathione. With the most interference-sensitive glucose meter, non-blood solutions of 1 mmol/L N-acetylcysteine, glutathione, cysteine, vitamin C, dihydrolipoate, and dithiothreitol mimicked the results seen on that glucose meter for 0.7, 1.0, 1.2, 2.6, 3.7 and 5.5 mmol/L glucose solutions, respectively. Glucose meter users should be alerted that some of these devices might produce spurious glucose results not only in patients on vitamin C therapy but also in those being administered other antioxidants. As discussed herein, the clinical relevance of the data is immediate in view of the current use of antioxidant therapies for disorders such as the metabolic syndrome, diabetes, cardiovascular diseases, and coronavirus disease 2019. |
| Databáze: | OpenAIRE |
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