Chromatin 3D – will it make understanding of cancer transformation finally possible?
| Autor: | Jolanta Kaszuba-Zwoińska, Irena Roterman, Zdzisław Wiśniowski, Leszek Konieczny, Grażyna Drabik |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
General Computer Science Cohesin Medicine (miscellaneous) Cancer Health Informatics Biology medicine.disease Biochemistry Genetics and Molecular Biology (miscellaneous) Cell biology Chromatin 03 medical and health sciences Transformation (genetics) 030104 developmental biology CTCF medicine |
| Zdroj: | Bio-Algorithms and Med-Systems. 14 |
| ISSN: | 1896-530X 1895-9091 |
| DOI: | 10.1515/bams-2018-0002 |
| Popis: | Despite enormous progress in molecular analysis of cancer cell genomes, the mechanism of tumorigenesis remains unclear. The information present in the genome is not limited to the DNA sequence itself. Indeed, a significant portion of this information is concealed in the spatial structure of chromatin. Ongoing scientific studies that focus on the three-dimensional structure of chromatin raise hopes of arriving at a general explanation of the cancer transformation phenomenon. |
| Databáze: | OpenAIRE |
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