Effect of Conjugated Equine Estrogens on Oxidative Metabolism in Middle-aged and Elderly Postmenopausal Women
| Autor: | Laurie A. Willhite, Reginald F. Frye, Gary R. Matzke, June LaValleur, Margaret R. Welch, Mary Beth O'Connell, Paul Kowal, John V. St. Peter |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Aging
medicine.medical_specialty CYP2D6 Arylamine N-Acetyltransferase medicine.drug_class CYP2C19 Dapsone Pharmacology Hydroxylation digestive system Mixed Function Oxygenases Cytochrome P-450 CYP1A2 Internal medicine Dextrorphan medicine Humans Pharmacology (medical) Mephenytoin Aged Estrogens Conjugated (USP) Chemistry CYP1A2 Cytochrome P-450 CYP2E1 Dextromethorphan Middle Aged Cytochrome P-450 CYP2C19 Postmenopause Endocrinology Cytochrome P-450 CYP2D6 Estrogen Female Metabolic Detoxication Phase I Aryl Hydrocarbon Hydroxylases medicine.drug |
| Zdroj: | The Journal of Clinical Pharmacology. 46:1299-1307 |
| ISSN: | 0091-2700 |
| DOI: | 10.1177/0091270006292249 |
| Popis: | The effects of conjugated equine estrogens (CEE) 0.625 mg daily on cytochrome P450 (CYP) were quantified in 12 middle-aged and 13 elderly postmenopausal women at baseline and 6 months later. CYP phenotype was characterized by caffeine (CYP1A2), chlorzoxazone (CYP2E1), dapsone (CYP, N-acetyltransferase 2), dextromethorphan (CYP2D6), and mephenytoin (CYP2C19) metabolism. CEE significantly decreased CYP1A2 (caffeine metabolic ratio: 0.57 +/- 0.20 before, 0.40 +/- 0.20 after, P = .001) and significantly increased CYP2D6 (dextromethorphan/dextrorphan ratio: 0.0116 +/- 0.0143 before, 0.0084 +/- 0.0135 after, P = .022) metabolism. CEE had no overall effect on CYP2C19, CYP2E1, CYP-mediated dapsone metabolism, and N-acetyltransferase 2. The dextromethorphan metabolic ratio decreased only in the seniors. The dapsone recovery ratio decreased in the middle-aged group and increased in the seniors. CEE significantly influenced CYP1A2, CYP2D6, and CYP-mediated dapsone oxidative metabolism but not CYP2C19, CYP2E1, or N-acetyltransferase 2 metabolism in postmenopausal women. Age influenced CYP2D6 metabolism and dapsone hydroxylation. |
| Databáze: | OpenAIRE |
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