Propagation of a Strain of Egg-Adapted Distemper Virus in Suckling Mice

Autor:	C. A. Brandly, H. G. Morse, T. L. Chow
Rok vydání:	1953
Předmět:	Ataxia Strain (chemistry) Canine distemper Reproduction Central nervous system Biology medicine.disease In ovo Virology General Biochemistry Genetics and Molecular Biology Hyperkinesis Virus Mice Dogs medicine.anatomical_structure Viruses medicine Animals Distemper medicine.symptom Paresis
Zdroj:	Experimental Biology and Medicine. 84:10-12
ISSN:	1535-3699 1535-3702
Popis:	SummaryTwo separate lines of the FXNO strain of egg-adapted canine distemper virus were passed intracerebrally in suckling mice 18 and 10 times, respectively. Both lines induced signs of protracted hyperkinesis. After the 7th passage central nervous system involvement became quite prominent and severe. Ataxia, muscular twitching, disequilibrium, paresis, and clonic spasms were common manifestations. The time of the first nervous disturbance decreased progressively from 8 days to 3 days in Line 1 and from 15 days to 4 days in Line 2. In ovo neutralization tests and ferret protection tests establish the identity of the mouse passaged agent with the original egg-adapted FXNO strain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f521a7815ce4a66dc11c401115d0bd8 https://doi.org/10.3181/00379727-84-20525 Zobrazit plný text záznamu