Morphometric characteristics of endometrial biopsies after different types of ovarian stimulation for infertility treatment
| Autor: | Elisabeth Johannisson, Heinz G. Bohnet, Annette Bonhoff, Olaf G.J. Naether |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Infertility endocrine system medicine.medical_specialty Menotropins medicine.drug_class Biopsy media_common.quotation_subject Biology Endometrium Chorionic Gonadotropin Clomiphene Human chorionic gonadotropin medicine Humans Ovulation Progesterone Menstrual cycle media_common Gynecology Estradiol medicine.diagnostic_test Ovary Obstetrics and Gynecology medicine.disease medicine.anatomical_structure Reproductive Medicine Female Gonadotropin Infertility Female Hormone |
| Zdroj: | Fertility and Sterility. 59:560-566 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)55800-2 |
| Popis: | Objective To investigate whether various types of ovarian stimulation induce differences in endometrial development at the midluteal phase in infertile women. Design Assessment of stromal and glandular compartments in endometrial biopsies using morphometric criteria. Setting Institute for Hormone and Fertility Research, Hamburg, Germany. Patients The study included 18 women after treatment with human menopausal gonadotropin (hMG)/human chorionic gonadotropin (hCG) (group I), 23 women after clomiphene citrate (CC)/hMG/hCG treatment (group II), and 12 women after CC stimulation (group III). Interventions Endometrial biopsies and blood samples were taken simultaneously in the early to midluteal phase. To assess the time of ovulation, hormone analysis and regular checks by ultrasonography were performed. Main Outcome Measures Morphometric evaluation of glandular and stromal structures revealed an impaired endometrial development after various treatment protocols. Conclusion Ovarian stimulation in infertile women results in most cases in an elevation of steroid levels; however, the occurrence of an inadequate endometrial development might have an unfavorable influence on the outcome of implantation. Therefore, these findings may be of importance to the choice of treatment for infertility. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|