Complete Pathological Remission of Locally Advanced, Unresectable Pancreatic Cancer (LAPC) after Intensified Neoadjuvant Chemotherapy
| Autor: | Ingo Hartlapp, Michael Scheurlen, Volker Kunzmann, Justus Müller, Christoph-Thomas Germer, C. Isbert, Hermann Einsele, Ulrich Steger, Werner Kenn |
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| Rok vydání: | 2013 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Organoplatinum Compounds Paclitaxel FOLFIRINOX medicine.medical_treatment Irinotecan urologic and male genital diseases Deoxycytidine Pancreatic cancer Internal medicine Antineoplastic Combined Chemotherapy Protocols Carcinoma Humans Medicine Aged Chemotherapy business.industry Remission Induction Hematology medicine.disease Gemcitabine Neoadjuvant Therapy Oxaliplatin Pancreatic Neoplasms Clinical trial Treatment Outcome Chemotherapy Adjuvant Camptothecin Female Fluorouracil business medicine.drug |
| Zdroj: | Oncology Research and Treatment. 36:123-125 |
| ISSN: | 2296-5262 2296-5270 |
| Popis: | Background: Unresectable locally advanced pancreatic cancer (LAPC) has an extremely poor prognosis. Results of neoadjuvant (radio-)chemotherapy approaches aiming at achieving resectability are currently not satisfactory. Case Report: We report the case of a 67-year-old woman with histologically confirmed pancreas carcinoma that was not resectable on first surgical exploration who achieved a well-documented complete pathological remission (pCR). The carcinoma became resectable after consecutive neoadjuvant treatment with nanoparticle albumin-bound (nab)-paclitaxel/gemcitabine and FOLFIRINOX chemotherapy regimens. Conclusion: This is the first reported LAPC case in which neoadjuvant chemotherapy alone has been shown to lead to demonstrated pCR. CA19-9 levels, but not imaging criteria, were useful for response prediction and timing of the Whipple's procedure. The findings in this case suggest possible conceptual changes in the treatment approach for LAPC, and indicate that the new effective chemotherapy regimens should be integrated into clinical trials for LAPC. |
| Databáze: | OpenAIRE |
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