A randomized controlled trial of exercise in spinal and bulbar muscular atrophy
| Autor: | Joshua G. Woolstenhulme, Derrick Fox, Cris Zampieri, Ellen W. Levy, Willie Ching, Michaele Smith, Sungyoung Auh, Joseph A. Shrader, Alice B. Schindler, Kenneth H. Fischbeck, Laboni Ghosh, Angela Kokkinis, Galen O. Joe, Ilona Kats, Christopher Grunseich, Bart Drinkard |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
business.industry Functional exercise General Neuroscience MEDLINE medicine.disease eye diseases law.invention body regions Spinal and bulbar muscular atrophy Physical medicine and rehabilitation stomatognathic system Randomized controlled trial law Medicine Neurology (clinical) business Research Articles |
| Zdroj: | Annals of Clinical and Translational Neurology |
| ISSN: | 2328-9503 |
| Popis: | Objective To determine the safety and efficacy of a home-based functional exercise program in spinal and bulbar muscular atrophy (SBMA). Methods Subjects were randomly assigned to participate in 12 weeks of either functional exercises (intervention) or a stretching program (control) at the National Institutes of Health in Bethesda, MD. A total of 54 subjects enrolled, and 50 completed the study with 24 in the functional exercise group and 26 in the stretching control group. The primary outcome measure was the Adult Myopathy Assessment Tool (AMAT) total score, and secondary measures included total activity by accelerometry, muscle strength, balance, timed up and go, sit-to-stand test, health-related quality of life, creatine kinase, and insulin-like growth factor-1. Results Functional exercise was well tolerated but did not lead to significant group differences in the primary outcome measure or any of the secondary measures. The functional exercise did not produce significantly more adverse events than stretching, and was not perceived to be difficult. To determine whether a subset of the subjects may have benefited, we divided them into high and low functioning based on baseline AMAT scores and performed a post hoc subgroup analysis. Low-functioning individuals receiving the intervention increased AMAT functional subscale scores compared to the control group. Interpretation Although these trial results indicate that functional exercise had no significant effect on total AMAT scores or on mobility, strength, balance, and quality of life, post hoc findings indicate that low-functioning men with SBMA may respond better to functional exercises, and this warrants further investigation with appropriate exercise intensity. |
| Databáze: | OpenAIRE |
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