Aging-Related Differences in Structural and Functional Interhemispheric Connectivity
| Autor: | Christian O'Reilly, Jeanne Townsend, Elizabeth Bock, Rebecca J. Theilmann, John D. Lewis |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Aging
Mediation (statistics) Visual perception genetic structures medicine.diagnostic_test Cognitive Neuroscience Splenium Electroencephalography Coherence (statistics) Corpus callosum White Matter Corpus Callosum White matter Cellular and Molecular Neuroscience Diffusion Magnetic Resonance Imaging medicine.anatomical_structure medicine Connectome Animals Original Article Psychology Neuroscience |
| Zdroj: | Cereb Cortex |
| ISSN: | 1460-2199 1047-3211 |
| DOI: | 10.1093/cercor/bhab275 |
| Popis: | There is substantial evidence of age-related declines in anatomical connectivity during adulthood, with associated alterations in functional connectivity. But the relation of those functional alterations to the structural reductions is unclear. The complexities of both the structural and the functional connectomes make it difficult to determine such relationships. We pursue this question with methods, based on animal research, that specifically target the interhemispheric connections between the visual cortices. We collect t1- and diffusion-weighted imaging data from which we assess the integrity of the white matter interconnecting the bilateral visual cortices. Functional connectivity between the visual cortices is measured with electroencephalography during the presentation of drifting sinusoidal gratings that agree or conflict across hemifields. Our results show age-related reductions in the integrity of the white matter interconnecting the visual cortices, and age-related increases in the difference in functional interhemispheric lagged coherence between agreeing versus disagreeing visual stimuli. We show that integrity of the white matter in the splenium of the corpus callosum predicts the differences in lagged coherence for the agreeing versus disagreeing stimuli; and that this relationship is mediated by age. These results give new insight into the causal relationship between age and functional connectivity. |
| Databáze: | OpenAIRE |
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