Vitamin D and Neurotrophin Levels and Their Impact on the Symptoms of Schizophrenia
| Autor: | Ivona Orlović, Danijel Crnković, Vjekoslav Peitl, Ante Silić, Branka Vidrih, Dalibor Karlović |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Brain-derived neurotrophic factor Nerve growth factor Neuregulin-1 Schizophrenia Vitamin D 03 medical and health sciences 0302 clinical medicine Neurotrophic factors Internal medicine mental disorders Nerve Growth Factor Vitamin D and neurology medicine Humans Neuregulin 1 Biological Psychiatry Positive and Negative Syndrome Scale biology business.industry Brain-Derived Neurotrophic Factor Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Neuropsychology and Physiological Psychology Endocrinology biology.protein Female business 030217 neurology & neurosurgery Neurotrophin |
| Popis: | Introduction: Vitamin D is involved in brain development and functioning, as well as in regulation of neurotrophic factors. Changes in the expression of those factors are possibly responsible for morphologic abnormalities and symptoms in patients suffering from schizophrenia. Objective: The main goal of this research was to investigate the interrelationship between vitamin D, nerve growth factors (NGF, brain-derived neurotrophic factor [BDNF], and neuregulin-1 [NRG1]), and schizophrenia symptom domains. Methods: This research included 97 inpatients diagnosed with schizophrenia. Schizophrenia symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). Blood samples were taken in order to analyze concentrations of vitamin D, BDNF, NRG1, and NGF growth factors. The obtained results were used in a multiple regression analysis. Results: The vitamin D concentration positively affected the concentration of NRG1 (F = 8.583, p = 0.005) but not the concentration of other investigated growth factors (BDNF and NGF). The clinical characteristics and symptom domains of schizophrenia seemed to be unaffected by the concentrations of vitamin D, BDNF, and NGF, while the NRG1 concentration significantly affected positive symptom domains of schizophrenia (F = 4.927, p = 0.030). Conclusion: The vitamin D concentration positively affected NRG1 levels but not schizophrenia symptomatology as measured by PANSS. The association between the two could be intermediated via NRG1. |
| Databáze: | OpenAIRE |
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