'Generalized' epileptic seizures elicited by electrical stimulation of the frontal lobe in man
| Autor: | M Bresson, J Bancaud, J Talairach, E Hemon, Morel P, S Geier, A. Bonis, P Buser |
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| Rok vydání: | 1974 |
| Předmět: |
Male
Epilepsy Adolescent Implanted electrodes General Neuroscience Spike-and-wave Stimulation Electroencephalography Electrical stimulations Electric Stimulation Intensity (physics) Frontal Lobe medicine.anatomical_structure Frontal lobe Cerebral cortex Cortex (anatomy) medicine Humans Female Neurology (clinical) Psychology Neuroscience |
| Zdroj: | Electroencephalography and clinical neurophysiology. 37(3) |
| ISSN: | 0013-4694 |
| Popis: | Five hundred and nine electrical stimulations were performed in the frontal lobes of 10 epileptic patients presenting “generalized” spontaneous attacks. These stimulations were carried out by means of stereotaxically implanted electrodes. Of these 509 stimulations, 150 induced either simple electro-clinical absences (67), complex absences (29), generalized tonic-clonic seizures (17), or only bilaterally synchronous, symmetrical spike and wave paroxysms (37). These responses, which in each case reproduced the spontaneous attacks of the patient, occurred from the beginning of stimulation and ended with it, except for the tonic-clonic seizures. The active electrodes were always located in the frontal lobe, particularly in the mesial cortex. Although the bilateral responses were related to stimulation of a restricted unilateral zone, most often they could be obtained from stimulation of either frontal lobe, in quasi-symmetrical regions. The type of electro-clinical response obtained was largely related to the parameters of stimulation: thus, in the same patient, a discharge of sub-clinical spikes and waves could become an absence and subsequently a “generalized” tonic-clonic seizure, when increasing the intensity or duration of the shocks. These results point to the preponderant role of the cerebral cortex, particularly that of its frontal portion, in elaboration of generalized epileptic attacks. |
| Databáze: | OpenAIRE |
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