Immunoenhancing Effects of Alprazolam, a Benzodiazepine Receptor Agonist
| Autor: | Ester Fride, Phil Skolnick, Prince K. Arora, Raymond Meng |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cytotoxicity
Immunologic Male Serum corticosterone Time Factors medicine.drug_class Lymphocyte proliferation Pharmacology Lymphocyte Activation General Biochemistry Genetics and Molecular Biology Mice Immune system History and Philosophy of Science medicine Animals Receptor Immunity Cellular Benzodiazepine Alprazolam Dose-Response Relationship Drug Chemistry GABAA receptor General Neuroscience Immunity Receptors GABA-A Chloride channel complex Killer Cells Natural medicine.drug |
| Zdroj: | Annals of the New York Academy of Sciences. 650:132-139 |
| ISSN: | 1749-6632 0077-8923 |
| DOI: | 10.1111/j.1749-6632.1992.tb49110.x |
| Popis: | The effects of alprazolam (ALP), a triazolobenzodiazepine with high affinity for "central" benzodiazepine receptors, were examined on several parameters of immune function in mice. NK, MLR, and mitogen-induced lymphocyte proliferation were all significantly increased 2 hr after administration of low doses (0.02-1.0 mg/kg) of ALP. Twenty four hr later, similar but less robust immunoenhancing effects were observed. These measures of immune functions were not affected by higher doses of ALP (5-10 mg/kg). The immunoenhancing effects of ALP did not appear related to serum corticosterone levels. These and other findings demonstrate that the GABA/benzodiazepine receptor chloride channel complex can bidirectionally modulate immune function. |
| Databáze: | OpenAIRE |
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