Latent associations of low serum amylase with decreased plasma insulin levels and insulin resistance in asymptomatic middle-aged adults
Autor: | Atsushi Aoki, Hiroshi Fuchigami, Shin-ichi Momomura, Masanobu Kawakami, Kei Nakajima, San-e Ishikawa, Masafumi Kakei, Hitoshi Sugawara, Toshitaka Muneyuki, Hiromi Munakata, Masashi Yoshida |
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Rok vydání: | 2012 |
Předmět: |
Male
Leptin lcsh:Diseases of the circulatory (Cardiovascular) system Time Factors Endocrinology Diabetes and Metabolism medicine.medical_treatment Body Mass Index Japan Risk Factors Odds Ratio Insulin Medicine Amylase Original Investigation 75-g oral glucose tolerance test Glucose tolerance test biology medicine.diagnostic_test Middle Aged Amylases HOMA-β Female QUICKI medicine.symptom Cardiology and Cardiovascular Medicine Adult medicine.medical_specialty Down-Regulation Risk Assessment Asymptomatic Insulin resistance Asian People Predictive Value of Tests Internal medicine Diabetes mellitus Humans HOMA-R Obesity Glucose Metabolism Disorders Chi-Square Distribution business.industry Glucose Tolerance Test medicine.disease Cross-Sectional Studies Logistic Models Endocrinology lcsh:RC666-701 Asymptomatic Diseases Multivariate Analysis biology.protein Serum amylase business Biomarkers |
Zdroj: | Cardiovascular Diabetology Cardiovascular Diabetology, Vol 11, Iss 1, p 80 (2012) |
ISSN: | 1475-2840 |
Popis: | Background Low serum amylase is likely to be associated with obesity and metabolic abnormalities, which are often accompanied by impaired insulin action. However, it is unclear whether low serum amylase is associated with impaired insulin action in clinical settings. Therefore, we investigated the associations of low serum amylase with plasma insulin levels, and obesity-related parameters, including leptin. Research design and methods We measured serum amylase, plasma insulin, obesity-related parameters such as leptin, cardiometabolic risk factors, and anthropometric parameters in a cross-sectional study of 54 asymptomatic subjects (mean age 48.6 ± 7.6 years) who were not being treated for diabetes. Results Body mass index (BMI) and plasma glucose at 120 min after a 75-g oral glucose tolerance test (OGTT) were significantly higher in subjects with low serum amylase (< 60 IU/l, n = 21) than in those with normal-to-high serum amylase (n = 33) (P = 0.04 and P = 0.004, respectively). In univariate correlation analysis, serum amylase was significantly correlated with BMI alone (r = –0.39, P = 0.004). By contrast, multivariate logistic analysis showed that each 1-SD increase in quantitative insulin sensitivity check index, and each 1-SD decrease in plasma insulin OGTT at 0 and 60 min, homeostasis model assessment of insulin resistance (HOMA)-R, and HOMA-β were significantly associated with low serum amylase, particularly after adjusting for BMI. When subjects were divided into three groups according to HOMA-R, serum amylase levels were significantly lower in subjects with HOMA-R > 2.5 (n = 23) compared with subjects with HOMA-R 1.6–2.5 (n = 10) (61.1 ± 13.6 U/ml versus 76.9 ± 20.5 U/ml, Bonferroni test, P = 0.02), but not compared with subjects with HOMA-R Conclusions These results suggest that after adjusting for BMI, low serum amylase is associated with decreased basal insulin levels and insulin secretion, as well as high insulin resistance. The nature of these associations remains to be elucidated in further studies. |
Databáze: | OpenAIRE |
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