Latent associations of low serum amylase with decreased plasma insulin levels and insulin resistance in asymptomatic middle-aged adults

Autor: Atsushi Aoki, Hiroshi Fuchigami, Shin-ichi Momomura, Masanobu Kawakami, Kei Nakajima, San-e Ishikawa, Masafumi Kakei, Hitoshi Sugawara, Toshitaka Muneyuki, Hiromi Munakata, Masashi Yoshida
Rok vydání: 2012
Předmět:
Male
Leptin
lcsh:Diseases of the circulatory (Cardiovascular) system
Time Factors
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Body Mass Index
Japan
Risk Factors
Odds Ratio
Insulin
Medicine
Amylase
Original Investigation
75-g oral glucose tolerance test
Glucose tolerance test
biology
medicine.diagnostic_test
Middle Aged
Amylases
HOMA-β
Female
QUICKI
medicine.symptom
Cardiology and Cardiovascular Medicine
Adult
medicine.medical_specialty
Down-Regulation
Risk Assessment
Asymptomatic
Insulin resistance
Asian People
Predictive Value of Tests
Internal medicine
Diabetes mellitus
Humans
HOMA-R
Obesity
Glucose Metabolism Disorders
Chi-Square Distribution
business.industry
Glucose Tolerance Test
medicine.disease
Cross-Sectional Studies
Logistic Models
Endocrinology
lcsh:RC666-701
Asymptomatic Diseases
Multivariate Analysis
biology.protein
Serum amylase
business
Biomarkers
Zdroj: Cardiovascular Diabetology
Cardiovascular Diabetology, Vol 11, Iss 1, p 80 (2012)
ISSN: 1475-2840
Popis: Background Low serum amylase is likely to be associated with obesity and metabolic abnormalities, which are often accompanied by impaired insulin action. However, it is unclear whether low serum amylase is associated with impaired insulin action in clinical settings. Therefore, we investigated the associations of low serum amylase with plasma insulin levels, and obesity-related parameters, including leptin. Research design and methods We measured serum amylase, plasma insulin, obesity-related parameters such as leptin, cardiometabolic risk factors, and anthropometric parameters in a cross-sectional study of 54 asymptomatic subjects (mean age 48.6 ± 7.6 years) who were not being treated for diabetes. Results Body mass index (BMI) and plasma glucose at 120 min after a 75-g oral glucose tolerance test (OGTT) were significantly higher in subjects with low serum amylase (< 60 IU/l, n = 21) than in those with normal-to-high serum amylase (n = 33) (P = 0.04 and P = 0.004, respectively). In univariate correlation analysis, serum amylase was significantly correlated with BMI alone (r = –0.39, P = 0.004). By contrast, multivariate logistic analysis showed that each 1-SD increase in quantitative insulin sensitivity check index, and each 1-SD decrease in plasma insulin OGTT at 0 and 60 min, homeostasis model assessment of insulin resistance (HOMA)-R, and HOMA-β were significantly associated with low serum amylase, particularly after adjusting for BMI. When subjects were divided into three groups according to HOMA-R, serum amylase levels were significantly lower in subjects with HOMA-R > 2.5 (n = 23) compared with subjects with HOMA-R 1.6–2.5 (n = 10) (61.1 ± 13.6 U/ml versus 76.9 ± 20.5 U/ml, Bonferroni test, P = 0.02), but not compared with subjects with HOMA-R Conclusions These results suggest that after adjusting for BMI, low serum amylase is associated with decreased basal insulin levels and insulin secretion, as well as high insulin resistance. The nature of these associations remains to be elucidated in further studies.
Databáze: OpenAIRE
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