Effect of hypoxia on metabolism and contractile function of the heart in rats with type 2 diabetes mellitus and abdominal obesity
| Autor: | V. T. Dolgikh, V. I. Chesnokov, M. V. Kolbina |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Diastole Aspartate transaminase In Vitro Techniques General Biochemistry Genetics and Molecular Biology Diabetes Mellitus Experimental Coronary circulation Internal medicine medicine Animals Obesity Abdominal obesity biology business.industry Myocardium Type 2 Diabetes Mellitus General Medicine Hypoxia (medical) medicine.disease Myocardial Contraction Cell Hypoxia Rats Endocrinology medicine.anatomical_structure Diabetes Mellitus Type 2 biology.protein medicine.symptom business Anaerobic exercise |
| Zdroj: | Bulletin of experimental biology and medicine. 138(3) |
| ISSN: | 0007-4888 |
| Popis: | Type 2 diabetes mellitus was modeled in newborn albino rat pups. Metabolism and contractile activity of isolated heart under conditions of hypoxia were studied on adult rats. Contractile activity of the myocardium in animals with type 2 diabetes mellitus and abdominal obesity decreased during hypoxia. It was manifested in a decrease in systolic and developed pressure and disturbances in diastolic relaxation of the myocardium. Damage to cell membranes and increased secretion of aspartate transaminase into the coronary circulation were observed under conditions of energy deficit and activation of the anaerobic pathway of energy production. These changes became more pronounced with increasing the period of hypoxic exposure. |
| Databáze: | OpenAIRE |
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