Oral Immunotherapy With Human Secretory Immunoglobulin A Improves Survival in the Hamster Model of Clostridioides difficile Infection
| Autor: | Mark Pulse, Mandago Maurice, Michael R. Simon, Estelle F. Chiari, William J. Weiss, Christoph von Eichel-Streiber, Stephen C. Brown, Karina Gisch, Kiessig Stephan T, Gerding Hanne Rieke |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Immunoglobulin A Secretory component medicine.medical_treatment Hamster chemical and pharmacologic phenomena law.invention 03 medical and health sciences Major Articles and Brief Reports 0302 clinical medicine fluids and secretions stomatognathic system law Vancomycin Cricetinae Immunology and Allergy Medicine Animals Humans Immunologic Factors Survival analysis biology business.industry Clostridioides difficile food and beverages Immunotherapy Anti-Bacterial Agents 030104 developmental biology Infectious Diseases Immunization 030220 oncology & carcinogenesis Immunology Immunoglobulin A Secretory biology.protein Recombinant DNA Clostridium Infections business medicine.drug |
| Zdroj: | J Infect Dis |
| ISSN: | 1537-6613 |
| Popis: | Co-administration of human secretory IgA (sIgA) together with subtherapeutic vancomycin significantly enhanced survival in the Clostridioides difficile infection (CDI) hamster model . Vancomycin (5 or 10 mg/kgx5 days) + healthy donor plasma sIgA/monomeric IgA (TIDx21 days) or hyperimmune sIgA/monomeric IgA (BIDx13 days) enhanced survival of CDI hamsters. Survival curves were significantly improved compared to vancomycin alone (p=0.018 and 0.039 by log-rank (Mantel-Cox) for healthy, and hyperimmune, sIgA, respectively. Passive immunization with sIgA made with recombinant human secretory component and IgA dimer/polymer from pooled human plasma can be administered orally, and prevents lethal infection in a partially treated CDI hamster model. |
| Databáze: | OpenAIRE |
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