Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis?
| Autor: | Carlos Henrique Fachin Bortoluci, Cleber Ferraresi, Luis Henrique Simionato, Beatriz Antoniassi Tavares, Rodrigo Leal de Paiva Carvalho, Claudio Alberto Tellez Soto, Geraldo Marco Rosa Junior, Kenia Mendes Rodrigues Castro |
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| Přispěvatelé: | Universidade Brasil, Universidade Estadual Paulista (Unesp), Bauru |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty LED therapy Low-level laser therapy Glucose control Cell Survival medicine.medical_treatment Biophysics Hindlimb chemistry.chemical_compound Diabetes mellitus Internal medicine Diabetes Mellitus medicine Increased glycogen Animals Humans Blood glucose Radiology Nuclear Medicine and imaging Low-Level Light Therapy Rats Wistar Muscle Skeletal Glycogen synthase Low level laser therapy Radiation Radiological and Ultrasound Technology biology Glycogen Lasers Muscles Dose-Response Relationship Radiation medicine.disease Endocrinology chemistry biology.protein Adenosine triphosphate |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2020-12-12T02:01:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-06-01 Photobiomodulation therapy (PBMT) has many effects on the energy metabolism of musculoskeletal tissue, such as increased glycogen and adenosine triphosphate synthesis. In addition, these effects may be due to a systemic blood glucose control. Twenty-four Wistar rats were randomly and equally allocated into four groups: sham, PBMT 10 J/cm2, PBMT 30 J/cm2 and PBMT 60 J/cm2. The animals were fasting for 6 h for blood glucose evaluations during pre-irradiation period, 1 h, 3 h and 6 h after PBMT. Muscle glycogen synthesis was measured 24 h after PBMT. This PBMT used a cluster of 69 LEDs (light-emitting diodes) with 35 red (630 ± 10 nm) and 34 infrared (850 ± 20 nm); 114 mW/cm2 for 90s (10 J/cm2), 270 s (30 J/cm2), 540 s (60 J/cm2) applied on large muscle areas (back and hind legs) of the animals. The 10 J/cm2 group showed lower blood glucose levels and glucose variability over 6 h (5.92 mg/dL) compared to the sham (13.03 mg/dL), 30 J/cm2 (7.77 mg/dL) and 60 J/cm2 (9.07 mg/dL) groups. The PBMT groups had the greatest increase in muscle glycogen (10 J/cm2 > 60 J/cm2 > 30 J/cm2 > sham), characterizing a triphasic dose-response of PBMT. There was a strong negative correlation between blood glucose variability over 6 h and muscle glycogen concentration for 10 J/cm2 group (r = −0.94; p < .001) followed by 30 J/cm2 group (r = −0.84; p < .001) and 60 J/cm2 group(r = −0.73; p < .006). These results suggest that PBMT can play a very important role in the control of blood glucose levels, and its possible mechanism of action is the induction of greater muscle glycogen synthesis independently of physical exercise. Post-Graduation Program in Biomedical Engineering Universidade Brasil Laboratory of Physiology and Human Performance São Paulo State University – UNESP, Bauru Universidade do Sagrado Coração (USC) Bauru Laboratory of Physiology and Human Performance São Paulo State University – UNESP, Bauru |
| Databáze: | OpenAIRE |
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