Exacerbations and healthcare resource utilization among COPD patients in a Swedish registry-based nation-wide study

Autor: Javaria Mona Khalid, Andreas Engstrom, Fabian Hoti, Jennifer Wall, Tobias Bäckström, Vasili Mushnikov, Gunnar Johansson
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Chronic bronchitis
Exacerbation
Respiratory Medicine and Allergy
Comorbidity
Severity of Illness Index
Pulmonary Disease
Chronic Obstructive
0302 clinical medicine
Adrenal Cortex Hormones
Registries
030212 general & internal medicine
Lungmedicin och allergi
Aged
80 and over
COPD
Burden of disease
Middle Aged
Pharmacoepidemiology
Symptom Flare Up
Bronchitis
Chronic
Hospitalization
Cardiovascular Diseases
Disease Progression
symbols
Health Resources
Female
Research Article
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Muscarinic Antagonists
Exacerbations
03 medical and health sciences
symbols.namesake
Severity of illness
Healthcare resource utilization
medicine
Humans
Poisson regression
Adrenergic beta-2 Receptor Agonists
Aged
Asthma
Sweden
Hospitalizations
lcsh:RC705-779
business.industry
lcsh:Diseases of the respiratory system
medicine.disease
030228 respiratory system
Emergency medicine
business
Zdroj: BMC Pulmonary Medicine, Vol 18, Iss 1, Pp 1-9 (2018)
BMC Pulmonary Medicine
ISSN: 1471-2466
DOI: 10.1186/s12890-018-0573-0
Popis: Background Exacerbations of chronic obstructive pulmonary disease (COPD) are an important measure of disease severity in terms of impaired disease progression, increased recovery time, healthcare resource utilization, overall morbidity and mortality. We aimed to quantify exacerbation and healthcare resource utilization rates among COPD patients in Sweden with respect to baseline treatments, exacerbation history, and comorbidities. Methods Patients with a COPD or chronic bronchitis (CB) diagnosis in secondary care at age of ≥40 years on 1.7.2009 were identified and followed until 1.7.2010 or death. Severe exacerbations were defined as hospitalizations due to respiratory disease, and healthcare resource utilization was measured by all-cause hospitalizations and secondary care visits. Poisson regression was used adjusting for age, gender, time since COPD/CB diagnosis, and Charlson comorbidity index. Results In 88,548 patients (54% females, mean age 72 years), previous respiratory hospitalizations and current high use of COPD medication (double or triple therapy) predicted an 8.3-fold increase in severe exacerbation rates and 1.8-fold increase in healthcare resource utilization rates in the following year, compared to patients without combination treatment and/or history of severe exacerbations. Conclusions COPD/CB patients with history of severe exacerbations and high use of COPD medication experienced a significantly increased rate of severe exacerbations and healthcare resource utilization during the one-year follow-up. Electronic supplementary material The online version of this article (10.1186/s12890-018-0573-0) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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