Biogenesis, Biologic Function and Clinical Potential of Exosomes in Different Diseases
Autor: | Amany Magdy Beshbishy, Saad Alghamdi, ThankGod E. Onyiche, Muhammad Zahoor, Nallely Rivero-Perez, Adrian Zaragoza-Bastida, Mohamed A. Ghorab, Ahmed Kh. Meshaal, Mohamed A. El-Esawi, Helal F. Hetta, Gaber El-Saber Batiha |
---|---|
Přispěvatelé: | 29228409 - Onyiche, ThankGod E. |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Cell signaling adipose-derived stem cell released exosomes exosomes Disease Biology Exosomes metabolic diseases lcsh:Technology lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine Adipose-derived stem cell released exosomes General Materials Science Tumor-derived exosomes lcsh:QH301-705.5 Instrumentation Fluid Flow and Transfer Processes mesenchymal stem cells tumor-derived exosomes lcsh:T Process Chemistry and Technology Mesenchymal stem cell General Engineering RNA Metabolic diseases lcsh:QC1-999 In vitro Microvesicles Computer Science Applications Cell biology 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 lcsh:TA1-2040 030220 oncology & carcinogenesis Mesenchymal stem cells lcsh:Engineering (General). Civil engineering (General) lcsh:Physics Biogenesis Function (biology) |
Zdroj: | Applied Sciences, Vol 10, Iss 4428, p 4428 (2020) |
ISSN: | 2076-3417 |
Popis: | Exosomes are extracellular vesicles (EVs) belonging to the nanovesicles family that function as signaling molecules between cells. After their first description in the late 1960s, interest in their potential as a research target has steadily increased. They are small secreted organelles with a single membrane that are well enriched in lipids, proteins, nucleic acids, and glycoconjugates. Exosomes take part in a larger communication network in which cells communicate between one another by DNA shuttling, proteins, RNA, and membrane-bound factors. The machinery of protein quality control occurs through the process termed “exosome biogenesis”. Furthermore, the pathway involved in intercellular movement of vesicles is vital in various aspects of human health and diseases. Due to their inherent properties, exosomes are currently being developed as potential therapeutic agents in a wide range of diseases including infectious and non-infectious diseases. Exosomes and other EVs sourced from Mesenchymal stem cells (MSCs) have been shown in different studies to possess therapeutic effects in diverse disease models either in vivo or in vitro. Some mechanisms and/or pathways that MSC-derived exosomes use to illustrate their therapeutic effect against some diseases have also been summarized. This review aims to highlight the recent findings and potential therapeutic application of exosomes in different diseases such as autoimmune, cardiovascular, obesity, neural, soft tissues, bone, and cartilage. |
Databáze: | OpenAIRE |
Externí odkaz: |