Effect of nutrition on postprandial glucose control in hospitalized patients with type 2 diabetes receiving fully automated closed-loop insulin therapy
| Autor: | Camillo Piazza, David Herzig, Roman Hovorka, Christophe Kosinski, Nicolas Banholzer, Stefan Feuerriegel, Mario Álvarez-Martínez, Lia Bally, Christos T. Nakas |
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| Přispěvatelé: | Banholzer, Nicolas [0000-0003-0138-6120], Herzig, David [0000-0003-1028-9445], Nakas, Christos T [0000-0003-4155-722X], Hovorka, Roman [0000-0003-2901-461X], Bally, Lia [0000-0003-1993-7672], Apollo - University of Cambridge Repository |
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Glucose control Endocrinology Diabetes and Metabolism medicine.medical_treatment 610 Medicine & health 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin Infusion Systems Diabetes mellitus Internal medicine Internal Medicine medicine Humans Insulin Meals Glycaemic control Insulin therapy Meal Cross-Over Studies business.industry digestive oral and skin physiology Bayes Theorem Carbohydrate medicine.disease Postprandial Period Postprandial glycaemic control Diabetes Mellitus Type 1 Fully automated Diabetes Mellitus Type 2 insulin therapy type 2 diabetes business |
| Zdroj: | Diabetes, Obesity and Metabolism, 23 (1) Banholzer, Nicolas; Herzig, David; Piazza, Camillo; Álvarez-Martínez, Mario; Nakas, Christos T; Kosinski, Christophe; Feuerriegel, Stefan; Hovorka, Roman; Bally, Lia (2021). Effect of nutrition on postprandial glucose control in hospitalized patients with type 2 diabetes receiving fully automated closed-loop insulin therapy. Diabetes, obesity & metabolism, 23(1), pp. 234-239. Wiley 10.1111/dom.14187 |
| ISSN: | 1462-8902 1463-1326 |
| DOI: | 10.17863/cam.57012 |
| Popis: | Fully automated closed‐loop insulin delivery may offer a novel way to manage diabetes in hospital. However, postprandial glycaemic control remains challenging. We aimed to assess the effect of nutritional intake on postprandial glucose control in hospitalized patients with type 2 diabetes receiving fully closed‐loop insulin therapy. The effects of different meal types and macronutrient composition on sensor glucose time‐in‐target (TIT, 3.9‐10.0 mmol/L) and mean sensor glucose were assessed with hierarchical linear models using a Bayesian estimation approach. TIT was lower and the mean sensor glucose slightly higher, after breakfast compared with lunch and dinner, whereas the insulin dose was higher. Across meals, when carbohydrates were replaced by fat, or to a lesser extent by protein, postprandial glucose control improved. For breakfast, a 3.9% improvement in TIT was observed when 10% of the energy from carbohydrates was replaced by fat. Improvements were slightly lower during lunch and dinner (3.2% and 3.4%) or when carbohydrates were replaced by protein (2.2 and 2.7%, respectively). We suggest that reducing carbohydrate at the expense of fat or protein, could further improve glucose control during fully closed‐loop insulin therapy in hospital. Diabetes, Obesity and Metabolism, 23 (1) ISSN:1462-8902 ISSN:1463-1326 |
| Databáze: | OpenAIRE |
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