Neutrophil/Lymphocyte Ratio Is an Independent Prognostic Factor in Elderly Patients with High-Grade Gliomas
| Autor: | Haodongfang Zhang, Xiaodong Niu, Youjun Gan, Qing Mao, Yuan Yang, Tianwei Wang, Jiaoming Li, Yanhui Liu, Xingwang Zhou |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Prognostic factor Neutrophils Lymphocyte Brain tumor Kaplan-Meier Estimate Gastroenterology World health Leukocyte Count 03 medical and health sciences 0302 clinical medicine Internal medicine Glioma Temozolomide medicine Overall survival Humans Lymphocyte Count Karnofsky Performance Status Aged Proportional Hazards Models Retrospective Studies High-Grade Glioma Aged 80 and over Brain Neoplasms business.industry fungi Mean age medicine.disease Combined Modality Therapy medicine.anatomical_structure Chemotherapy Adjuvant 030220 oncology & carcinogenesis Female Radiotherapy Adjuvant Surgery Neurology (clinical) Neoplasm Grading business Craniotomy 030217 neurology & neurosurgery |
| Zdroj: | World Neurosurgery. 127:e261-e267 |
| ISSN: | 1878-8750 |
| DOI: | 10.1016/j.wneu.2019.03.085 |
| Popis: | The present study was performed to investigate the prognostic role of the preoperative neutrophil/lymphocyte ratio (NLR) in elderly patients with high-grade glioma.We collected the data from elderly patients (age ≥65 years) who had been diagnosed with high-grade glioma in our hospital from December 2014 to January 2018. The preoperative NLR was evaluated in univariate and multivariate models to examine their effect on overall survival (OS).The study included 135 elderly patients (World Health Organization grade III, n = 22; grade IV, n = 113) with a mean age 70.61 ± 4.60 years. The mean NLR was 3.98 ± 3.28. The optimal NLR cutoff for predicting OS was 3. Of the 135 patients, 65 (48.1%) had a baseline NLR of ≥3 and 70 (51.9%) a baseline NLR3. For patients with an NLR of ≥3 and NLR3, the mean OS was 9.6 months and 17.1 months, respectively. The results showed that age, gender, tumor location, preoperative Karnofsky performance scale score, extent of resection (EOR), and postoperative adjuvant therapy were not associated with the NLR. The tumor grade, neutrophil count, and lymphocyte count were significantly associated with the NLR (P0.001). On univariate analysis, tumor grade, preoperative Karnofsky performance scale score ≥80, EOR, frontal tumor, adjuvant radiotherapy plus temozolomide, NLR of ≥3, and lymphocyte count of ≥1.6 × 10A high NLR was an unfavorable predictor of prognosis for elderly patients with high-grade glioma. |
| Databáze: | OpenAIRE |
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