Infection due to acyclovir resistant herpes simplex virus in patients undergoing allogeneic hematopoietic stem cell transplantation

Autor: J.-N. Dauendorffer, A.-S. Carret, P Bordigoni, Véronique Venard, A. Le Faou, D Edert, Daniele Corsaro
Rok vydání: 2001
Předmět:
Foscarnet
Male
viruses
DNA Mutational Analysis
Acyclovir
Graft vs Host Disease
medicine.disease_cause
chemistry.chemical_compound
Simplexvirus
Child
Bone Marrow Transplantation
Lymphoma
Non-Hodgkin
virus diseases
Valine
General Medicine
Valaciclovir
Leukemia
Myeloid
Valacyclovir
Acute Disease
Female
Cidofovir
medicine.drug
Adolescent
medicine.drug_class
Mutation
Missense
Organophosphonates
Biology
Antiviral Agents
Thymidine Kinase
Virus
Cytosine
Immunocompromised Host
Viral Proteins
Organophosphorus Compounds
Leukemia
Myelogenous
Chronic
BCR-ABL Positive
Drug Resistance
Viral
medicine
Humans
Point Mutation
Transplantation
Homologous
Aciclovir
Codon
Salvage Therapy
Herpes Simplex
Virology
Transplantation
Herpes simplex virus
chemistry
Amino Acid Substitution
Immunology
Virus Activation
Antiviral drug
Zdroj: Pathologie-biologie. 49(7)
ISSN: 0369-8114
Popis: Over an eight-month period from October 1997 to May 1998, four patients who had received bone marrow transplant (BMT) from unrelated donor presented with severe mucosal cutaneous infections involving aciclovir resistant herpes simplex virus 1 (HSV-1). The four isolates were aciclovir (ACV) resistant, three of which were also foscarnet resistant as determined by the dye uptake method. The sequencing of the thymidine kinase (TK) gene did not permit to establish a relation between mutations and resistance to ACV. Three patients were considered as clinically cured of their HSV infection by replacement of ACV or foscarnet with either valaciclovir (one case) or cidofovir (two cases) but eventually two of them died of graft vs host disease. One patient died of extensive HSV infection despite administration of cidofovir. This study emphasizes the importance of monitoring the herpes virus resistance to antiviral drugs in bone marrow transplant recipients and the usefulness of the evaluation of novel antiviral drug for treatment of infections due to strains of HSV resistant to ACV and foscarnet that occur in about 5% of immunocompromised patients.
Databáze: OpenAIRE
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