Recurrence rate of lentigo maligna after micrographically controlled staged surgical excision
| Autor: | S. Koljenović, M.B.A. van Doorn, L.M. Prens, Errol P. Prens, Karin Greveling, K. Munte, K. D. de Vries |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms SURGERY medicine.medical_treatment Melanoma in situ Dermatology Lentigo maligna THERAPY Hutchinson's Melanotic Freckle 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Postoperative Complications medicine Mohs surgery Humans Retrospective Studies Scalp MELANOMA IN-SITU business.industry Wide local excision Margins of Excision Retrospective cohort study medicine.disease Mohs Surgery TRENDS Surgery Cytopathology Head and Neck Neoplasms Patient Satisfaction 030220 oncology & carcinogenesis Surgical excision Female Facial Neoplasms Neoplasm Recurrence Local business |
| Zdroj: | BRITISH JOURNAL OF DERMATOLOGY, 174(3), 588-593. Wiley |
| ISSN: | 0007-0963 |
| DOI: | 10.1111/bjd.14325 |
| Popis: | Summary Background Lentigo maligna is a slowly growing melanoma in situ. Current guidelines advise wide local excision with a margin of 5 mm as the treatment of first choice, which has recurrence rates ranging from 6% to 20%. Objectives To determine retrospectively the recurrence rate of lentigo maligna after staged surgical excision. Methods Records of all patients with lentigo maligna treated with our method of staged surgical excision between 2002 and 2011 were retrieved. To identify recurrences we used the computer program Sympathy, which is linked to PALGA, a nationwide network and registry of histo- and cytopathology in the Netherlands. Results We identified 100 patients, who were treated with staged surgical excision with 100% immunohistopathological control of lateral margins. Digital pictures were used to facilitate orientation during the several stages of surgery. After a mean follow-up of 60 months, four patients had a recurrence, after 37, 58, 74 and 77 months of follow-up. Conclusions Staged surgical excision is superior in clearance and recurrence rates to wide local excision for lentigo maligna and should be considered as the treatment of first choice in national and international guidelines. |
| Databáze: | OpenAIRE |
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