Sarcoidosis in an Italian province. Prevalence and environmental risk factors

Autor: Augusto Alberto Pastorelli, Deborah Beghè, Ernesto Crisafulli, Gloria Saccani, Marilena Muscarella, Luca Dall'Asta, Giuseppina Bertorelli, Massimo Corradi, Paolo Stacchini, Marina Aiello, Claudia Garavelli, Alfredo Chetta
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Genetics and Molecular Biology (all)
Male
Topography
lcsh:Medicine
Disease
Plant Science
Biochemistry
Analytical Chemistry
0302 clinical medicine
Mathematical and Statistical Techniques
Environmental protection
Mountains
Risk Factors
Epidemiology
Medicine and Health Sciences
Prevalence
Ethnicities
Mineral particles
Patchy distribution
030212 general & internal medicine
lcsh:Science
Principal Component Analysis
Multidisciplinary
Middle Aged
Pollution
Terrestrial Environments
Italian People
Chemistry
N/A
Italy
Bioaccumulation
Lichenology
Physical Sciences
Engineering and Technology
Female
Sarcoidosis
Statistics (Mathematics)
Research Article
Environmental Monitoring
Adult
medicine.medical_specialty
Environmental Engineering
Inflammatory Diseases
Biology
Research and Analysis Methods
03 medical and health sciences
Altitude
Environmental risk
Rheumatology
Environmental health
Air Pollution
medicine
Humans
Statistical Methods
Aged
Landforms
lcsh:R
Ecology and Environmental Sciences
Biology and Life Sciences
Geomorphology
Geographic Information Systems
Biochemistry
Genetics and Molecular Biology (all)
Agricultural and Biological Sciences (all)
medicine.disease
Trace Elements
030228 respiratory system
People and Places
Multivariate Analysis
Earth Sciences
lcsh:Q
Population Groupings
Mathematics
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 5, p e0176859 (2017)
ISSN: 1932-6203
Popis: Background and aim Sarcoidosis is a systemic granulomatous inflammatory disease whose causes are still unknown and for which epidemiological data are often discordant. The aim of our study is to investigate prevalence and spatial distribution of cases, and identify environmental exposures associated with sarcoidosis in an Italian province. Methods After georeferentiation of cases, the area under study was subdivided with respect to Municipality and Health Districts and to the altitude in order to identify zonal differences in prevalence. The bioaccumulation levels of 12 metals in lichen tissues were analyzed, in order to determine sources of air pollution. Finally, the analysis of the correlation between metals and between pickup stations was performed. Results 223 patients were identified (58.3% female and 41.7% male of total) and the mean age was 50.6±15.4 years (53.5±15.5 years for the females and 46.5±14.4 for the males). The mean prevalence was 49 per 100.000 individuals. However, we observed very heterogeneous prevalence in the area under study. The correlations among metals revealed different deposition patterns in lowland area respect to hilly and mountain areas. Conclusions The study highlights a high prevalence of sarcoidosis cases, characterized by a very inhomogeneous and patchy distribution with phenomena of local aggregation. Moreover, the bioaccumulation analysis was an effective method to identify the mineral particles that mostly contribute to air pollution in the different areas, but it was not sufficient to establish a clear correlation between the onset of sarcoidosis and environmental risk factors.
Databáze: OpenAIRE
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