Tissue expression and sero-reactivity of tumor-specific antigens in colorectal cancer
| Autor: | Michael Keese, Dirk Schadendorf, Axel Gerhardt, Stefan B. Eichmüller, Dirk Usener, Jörg Sturm |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte endocrine system Cancer Research Pathology medicine.medical_specialty Colorectal cancer medicine.medical_treatment law.invention Antigen Antigens Neoplasm law medicine Humans RNA Messenger Gene Membrane Glycoproteins biology Reverse Transcriptase Polymerase Chain Reaction business.industry Immunotherapy medicine.disease Neoplasm Proteins Oncology Cell culture Recombinant DNA biology.protein Antibody NY-ESO-1 Colorectal Neoplasms business Melanoma-Specific Antigens |
| Zdroj: | Cancer Letters. 208:197-206 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2003.11.021 |
| Popis: | The expression of 14 individual and two groups of tumor antigens was characterized for colorectal carcinoma by RT-PCR using 26 colorectal carcinoma specimens, eight cell lines, six samples of patients with inflammatory bowl diseases, and nine specimens from different locations of an individual patient with a metastasized rectal carcinoma. The most frequently detected mRNAs were MAGE-A1 (58%), GAGE-3-7 (54%), and cTAGE-5a (31%). At medium frequencies (12-19%) we found cTAGE-1, MAGE-A2, se57-1, RAGE-4, and GAGE-1,2,8, while other tumor antigens were expressed rarely ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect