Esophageal Cancer
| Autor: | Robert J. Cerfolio, Carolyn Apperson-Hansen, M. Pera, Toni Lerut, Chen Lq, André Duranceau, James D. Luketich, Jarmo A. Salo, Chadrick E. Denlinger, Eugene H. Blackstone, Simon Law, Hemant Ishwaran, Thomas J. Watson, Paul H. Schipper, Walter J. Scott, Gail Darling, Wayne L. Hofstetter, Thomas W. Rice, Mark S. Allen, Valerie W. Rusch, Kenneth A. Kesler |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Lymphatic metastasis Pathology Esophageal Neoplasms medicine.medical_treatment Datasets as Topic Adenocarcinoma Article Machine Learning 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Carcinoma Humans Neoplasm Invasiveness Lymph node Aged Neoplasm Staging business.industry Esòfag -- Càncer Cancer Middle Aged Esophageal cancer medicine.disease 3. Good health Esophagectomy medicine.anatomical_structure Lymphatic Metastasis 030220 oncology & carcinogenesis Carcinoma Squamous Cell Lymph Node Excision Female 030211 gastroenterology & hepatology Surgery Lymphadenectomy Neoplasm staging Lymph Nodes business |
| Zdroj: | Annals of Surgery. 265:122-129 |
| ISSN: | 0003-4932 |
| DOI: | 10.1097/sla.0000000000001594 |
| Popis: | OBJECTIVES: To identify the associations of lymph node metastases (pN+), number of positive nodes, and pN subclassification with cancer, treatment, patient, geographic, and institutional variables, and to recommend extent of lymphadenectomy needed to accurately detect pN+ for esophageal cancer. SUMMARY BACKGROUND DATA: Limited data and traditional analytic techniques have precluded identifying intricate associations of pN+ with other cancer, treatment, and patient characteristics. METHODS: Data on 5806 esophagectomy patients from the Worldwide Esophageal Cancer Collaboration were analyzed by Random Forest machine learning techniques. RESULTS: pN+, number of positive nodes, and pN subclassification were associated with increasing depth of cancer invasion (pT), increasing cancer length, decreasing cancer differentiation (G), and more regional lymph nodes resected. Lymphadenectomy necessary to accurately detect pN+ is 60 for shorter, well-differentiated cancers ( |
| Databáze: | OpenAIRE |
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