Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence

Autor: Gentile, F. R., Primi, R., Baldi, E., Compagnoni, S., Mare, C., Contri, E., Reali, F., Bussi, D., Facchin, F., Currao, A., Bendotti, S., Savastano, S., Cuzzoli, A., Pagliosa, A., Matiz, G., Russo, A., Vecchi, A. L., Fantoni, C., Parogni, P., Fava, C., Franzosi, C., Vimercati, C., Franchi, D., Storti, E., Rizzi, U., Ruggeri, S., Taravelli, E., Giovenzana, F., Buetto, G., Villa, G. F., Botteri, M., Caico, S. I., Bergamini, G., Cominesi, I. R., Carnevale, L., Caresani, M., Luppi, M., Migliori, M., Centineo, P., Genoni, P., Bertona, R., De Ponti, R., Buratti, S., Danzi, G. B., Marioni, A., Palo, A., De Pirro, A., Molinari, S., Sgromo, V., Musella, V., Paglino, M., Mojoli, F., Lusona, B., Pagani, M., Curti, M., Klersy, C., Campi, S., Castiglioni, B., Piccolo, U., Cazzaniga, M., Passarelli, I., Perone, G., Panni, G., Ghiraldin, D., Bettari, L., Moschini, L., Zanotti, L.
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Atmospheric Science
Meteorological Concepts
Epidemiology
Air pollution
Cardiovascular Medicine
Logistic regression
medicine.disease_cause
Geographical locations
chemistry.chemical_compound
Medical Conditions
Medicine and Health Sciences
Cardiac Arrest
Emergency medical services
Medicine
media_common
Air Pollutants
Multidisciplinary
Geography
Organic Compounds
Incidence
Incidence (epidemiology)
Pollution
Europe
Chemistry
Italy
Cardiovascular Diseases
Physical Sciences
Research Article
media_common.quotation_subject
Science
Cardiology
Meteorology
Air Pollution
Environmental health
Humans
Nitrogen dioxide
European Union
Air quality index
Pollutant
business.industry
Ecology and Environmental Sciences
Organic Chemistry
Chemical Compounds
Humidity
Benzene
Environmental Exposure
Logistic Models
chemistry
Medical Risk Factors
Earth Sciences
Out-of-Hospital Cardiac Arrest
People and places
business
Zdroj: PLoS ONE, Vol 16, Iss 8, p e0256526 (2021)
PLoS ONE
ISSN: 1932-6203
Popis: Background Pollution has been suggested as a precipitating factor for cardiovascular diseases. However, data about the link between air pollution and the risk of out-of-hospital cardiac arrest (OHCA) are limited and controversial. Methods By collecting data both in the OHCA registry and in the database of the regional agency for environmental protection (ARPA) of the Lombardy region, all medical OHCAs and the mean daily concentration of pollutants including fine particulate matter (PM10, PM2.5), benzene (C6H6), carbon monoxide (CO), nitrogen dioxide (NO2), sulphur dioxide (SO2), and ozone (O3) were considered from January 1st to December 31st, 2019 in the southern part of the Lombardy region (provinces of Pavia, Lodi, Cremona and Mantua; 7863 km2; about 1550000 inhabitants). Days were divided into high or low incidence of OHCA according to the median value. A Probit dose-response analysis and both uni- and multivariable logistic regression models were provided for each pollutant. Results The concentrations of all the pollutants were significantly higher in days with high incidence of OHCA except for O3, which showed a significant countertrend. After correcting for temperature, a significant dose-response relationship was demonstrated for all the pollutants examined. All the pollutants were also strongly associated with high incidence of OHCA in multivariable analysis with correction for temperature, humidity, and day-to-day concentration changes. Conclusions Our results clarify the link between pollutants and the acute risk of cardiac arrest suggesting the need of both improving the air quality and integrating pollution data in future models for the organization of emergency medical services.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje