Comparative Analysis of Pathobiochemical Changes in Major Depression and Post-Traumatic Stress Disorder
| Autor: | Elena Rybnikova, Mikhail Yu. Zenko, Konstantin N Stupin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Depressive Disorder
Major Neurotransmitter Agents business.industry Traumatic stress Brain General Medicine Biochemistry 030227 psychiatry Stress Disorders Post-Traumatic Fight-or-flight response 03 medical and health sciences 0302 clinical medicine Etiology Humans Medicine Glucocorticoid hormones business Glucocorticoids Neuroscience Stress Psychological 030217 neurology & neurosurgery Depression (differential diagnoses) |
| Zdroj: | Biochemistry (Moscow). 86:729-736 |
| ISSN: | 1608-3040 0006-2979 |
| DOI: | 10.1134/s0006297921060109 |
| Popis: | Abstract Comparative analysis of available literature data on the pathogenetic neuroendocrine mechanisms of depression and post-traumatic stress disorder (PTSD) is provided in this review to identify their common features and differences. We discuss the multidirectional modifications of the activity of cortical and subcortical structures of the brain, levels of neurotransmitters and their receptors, and functions of the hypothalamic-pituitary-adrenocortical axis in depression and PTSD. The analysis shows that these disorders are examples of opposite failures in the system of adaptive stress response of the body to stressful psychotraumatic events. On this basis, it is concluded that the currently widespread use of similar approaches to treat these disorders is not justified, despite the significant similarity of their anxiety-depressive symptoms; development of differential therapeutic strategies is required. |
| Databáze: | OpenAIRE |
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