Correlation of c-MET expression with clinical characteristics and the prognosis of colorectal cancer
| Autor: | Qiumei Dong, Dongyang Yang, Fei Xu, Dong Ma, Xiaorong Lai, Ying Li, Sipei Wu, Chao Liu, Zijun Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Neuroblastoma RAS viral oncogene homolog
C-Met business.industry Colorectal cancer Gastroenterology Perineural invasion Gene mutation medicine.disease medicine.disease_cause chemistry.chemical_compound Exon Oncology chemistry Cancer research Immunohistochemistry Medicine Original Article KRAS business |
| Zdroj: | J Gastrointest Oncol |
| ISSN: | 2219-679X 2078-6891 |
| DOI: | 10.21037/jgo-21-536 |
| Popis: | Background The proto-oncogene c-MET (mesenchymal-epithelial transition factor gene) plays a critical role in cellular proliferation, survival, migration, and invasion in cancers. The aim of this study is to explore the relationship between c-MET expression and the clinicopathological characteristics of colorectal cancer (CRC) patients. Methods A total of 337 enrolled patients were collected in present study. Here, the c-MET and EGFR expression were detected by immunohistochemistry (IHC). The mutational statuses of KRAS in exons 2, 3, and 4, NRAS in exons 2, 3, and 4, and BRAF in exon 15 from formalin-fixed sections were detected by direct DNA sequencing. Results Our results showed that high c-MET expression was significantly associated with tumor perineural invasion (P=0.007) and gender (P=0.016). High level c-MET expression (c-MET-high) in the primary tumors was observed in 68.2% of patients. In the 337 enrolled patients, 43.2% of patients had KRAS mutations, 3.3% of patients had NRAS mutations, and 4.7% of patients had BRAF mutations. However, KRAS, NRAS, and BRAF gene mutations had no association with c-MET protein levels in primary tumors. Additionally, c-MET protein expression had a strong correlation with EGFR expression (P=0.002). The survival time was not significantly longer for patients with c-MET-high primary tumors than for those with c-MET-low primary tumors. Conclusions c-MET immunohistochemistry was significantly higher in primary tumors with perineural invasion, female gender, and EGFR high expression. However, c-MET-high in the primary tumors was not significantly associated with longer survival compared with c-MET-low tumors. Further studies are required to investigate c-MET as potential molecular marker of progression and to test the possibility of its incorporation as a new therapeutic target. |
| Databáze: | OpenAIRE |
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