Study of clofibric acid distribution, metabolism and model, in crab pachygrapsus marmoratus (decapoda, brachyura)
| Autor: | Jacques Lautier, Jean-Louis Chanal, Jean-G. Lagarrigue, Jacques Guibert |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
medicine.medical_specialty Brachyura Immunology Ovary Biology Models Biological Lethal Dose 50 Toxicology chemistry.chemical_compound Sex Factors Pharmacokinetics Hemolymph Internal medicine medicine Animals Clofibrate Pharmacology Decapoda Stomach Clofibric acid Metabolism biology.organism_classification Kinetics Endocrinology medicine.anatomical_structure chemistry Pachygrapsus marmoratus Female Hepatopancreas |
| Zdroj: | Comparative Biochemistry and Physiology Part C: Comparative Pharmacology. 58:173-175 |
| ISSN: | 0306-4492 |
| Popis: | 1. 1. The DL 50 of clofibric acid which is injected intravenously in crab Pachygrapsus marmoratus is 173.5 mg/kg. 2. 2. Hypolipidemic drug distribution is distinct according to the organ. The fixation power of stomach and hepatopancreas is high; on the other hand, crab muscle fixes less clofibric acid than a mammal's; ovary radioactivity is higher than the testicular one. 3. 3. The difference between males and females seems to consist in higher urinary excretion of labelled compound in males. 4. 4. Metabolisation which begins after 8 hr increases slowly and is more importan 5. 5. Pharmacokinetic model indicates that clofibric acid is distinctly distributed according to organs and sex. |
| Databáze: | OpenAIRE |
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