Outcomes of Stage III NSCLC with occult primary vs. known primary lesions
| Autor: | James Huang, David R. Jones, Yonatan Bardash, Darren J. Buonocore, Paul B. Romesser, Jamie E. Chaft, Abraham J. Wu, Andreas Rimner |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Oncology Male Cancer Research medicine.medical_specialty Multivariate analysis Lung Neoplasms Stage III NSCLC Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine Carcinoma Non-Small-Cell Lung Positron Emission Tomography Computed Tomography medicine Humans Neoplasm Metastasis Lung cancer neoplasms Definitive radiotherapy Aged Neoplasm Staging Retrospective Studies business.industry Hazard ratio medicine.disease Occult Primary tumor Survival Analysis respiratory tract diseases 030104 developmental biology Treatment Outcome 030220 oncology & carcinogenesis Cohort Neoplasms Unknown Primary Female Neoplasm Recurrence Local business |
| Zdroj: | Lung cancer (Amsterdam, Netherlands). 127 |
| ISSN: | 1872-8332 |
| Popis: | OBJECTIVES: Occult primary non-small cell lung cancer (OP-NSCLC) involving mediastinal lymph nodes without an identifiable primary tumor is a rare presentation, with little known about how outcomes compare to typical Stage III NSCLC. We reviewed our experience treating OP-SCLC with definitive radiotherapy and compared outcomes to a contemporary cohort of stage III NSCLC patients. MATERIALS AND METHODS: We reviewed 605 patients with stage III NSCLC staged with PET-CT and treated with definitive radiotherapy between 1998 and 2013. Overall survival, intrathoracic control, and freedom from distant metastasis were computed using Kaplan-Meier method and logrank comparison. Cox hazard ratios were used to perform univariate and multivariate analyses. RESULTS: Twenty-one patients were identified with OP-NSCLC (3.5%). Patients with OP-NSCLC, as compared to known primary NSCLC, had significantly better 5-year rates of intrathoracic control (83.5% vs. 24.2%, P |
| Databáze: | OpenAIRE |
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