Acceptability and feasibility of two interventions in the MooDFOOD Trial:A food-related depression prevention randomised controlled trial in overweight adults with subsyndromal symptoms of depression

Autor: Ulrich Hegerl, Edward Watkins, Miquel Roca, Matthew Owens, Mariska Bot, Ingeborg Annemarie Brouwer, Elisabeth Kohls, Brenda Penninx, Gerard van Grootheest, Mieke Cabout, Margalida Gili, Marjolein Visser, Bep Verkerk, Nadine Paans, Carisha Thesing, Deborah Gibson-Smith, Melany Horsfall, Lena Weiss, Amy Romijn, Hannah Bunce, Owain Winfield, Harriet Bunker-Smith, Fern Durbridge, Caterina Versari Molinares, Atikah Sapar, Miquel Tortella, Clara Homar Covas, M Angeles Pérez-Ara, Adoración Castro Gracia, José Luis Reig, Jana Hoesel, Ezgi Dogan, Sabrina Baldofski, Nicole Mauche
Přispěvatelé: Health Sciences, APH - Health Behaviors & Chronic Diseases, Nutrition and Health, APH - Aging & Later Life, APH - Societal Participation & Health, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, AGEM - Endocrinology, metabolism and nutrition, APH - Digital Health
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Owens, M, Watkins, E, Bot, M, Brouwer, I A, Roca, M, Kohls, E, Penninx, B, Van Grootheest, G, Cabout, M, Hegerl, U, Gili, M & Visser, M 2020, ' Acceptability and feasibility of two interventions in the MooDFOOD Trial : A food-related depression prevention randomised controlled trial in overweight adults with subsyndromal symptoms of depression ', BMJ Open, vol. 10, no. 9, e034025 . https://doi.org/10.1136/bmjopen-2019-034025
BMJ Open, Vol 10, Iss 9 (2020)
BMJ Open
BMJ Open, 10(9):e034025, 1-11. BMJ Publishing Group
MooDFOOD Prevention Trial Investigators 2020, ' Acceptability and feasibility of two interventions in the MooDFOOD Trial : a food-related depression prevention randomised controlled trial in overweight adults with subsyndromal symptoms of depression ', BMJ Open, vol. 10, no. 9, e034025, pp. 1-11 . https://doi.org/10.1136/bmjopen-2019-034025
BMJ Open, 10(9):e034025. BMJ Publishing Group
ISSN: 2044-6055
Popis: Objectives We report on the acceptability, feasibility, dose-response relationship and adherence of two nutritional strategies to improve mood (multinutrient supplements; food-related behavioural activation (F-BA)) studied in a randomised controlled depression prevention trial (the Multi-country cOllaborative project on the rOle of Diet, Food-related behaviour, and Obesity in the prevention of Depression (MooDFOOD) Trial). We also assessed baseline determinants of adherence and assessed whether better adherence resulted in lower depressive symptoms. Design Randomised controlled trial with a 2x2 factorial design conducted between 2015 and 2017. Setting Germany, the Netherlands, UK and Spain. Participants Community sample of 1025 overweight adults with elevated depressive symptoms without a current episode of major depressive disorder. Main eligibility criteria included age (18-75 years), being overweight or obese, and having at least mild depressive symptoms, shown by a Patient Health Questionnaire Score of >= 5. A total of 76% of the sample was retained at the 12-month follow-up. Interventions Daily nutritional supplements versus pill placebo or an F-BA therapy, delivered in individual and group sessions versus no behavioural intervention over a 1-year period. Primary and secondary outcome measures Primary outcome: self-reported acceptability of the interventions. Secondary outcomes: adherence and self-reported depressive symptoms. Results Most participants reported that the F-BA was acceptable (83.61%), feasible to do (65.91%) and would recommend it to a friend (84.57%). Individual F-BA sessions (88.10%) were significantly more often rated as positive than group F-BA sessions (70.17%) and supplements (28.59%). There were statistically significant reductions in depressive symptoms for those who both adhered to the F-BA intervention and had a history of depression (B=-0.08, SE=0.03, p=0.012) versus those who had no history of depression. Supplement intake had no effect on depressive symptoms irrespective of adherence. Conclusions F-BA may have scope for development as a depression prevention intervention and public health strategy but further refinement and testing are needed.
This work was supported by the European Union FP7 MooDFOOD Project 'Multi-country collaborative project on the role of Diet, food related behaviour, and Obesity in the prevention of Depression' (grant agreement no. 613598). This work is supported in the UK by the National Institute for Health Research (NIHR), through the Primary Care Research Network and the NIHR Exeter Clinical Research Facility.
Databáze: OpenAIRE
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