Activity-wheel running blunts suppression of splenic natural killer cell cytotoxicity after sympathectomy and footshock
| Autor: | S. Hong, Gaylen L. Edwards, B. N. Bunnell, Jesus Soares, Donald L. Evans, Liliana Jaso-Friedmann, Rodney K. Dishman |
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| Rok vydání: | 2001 |
| Předmět: |
Nervous system
Cytotoxicity Immunologic medicine.medical_specialty Sympathetic nervous system animal structures medicine.medical_treatment Experimental and Cognitive Psychology Biology Motor Activity Natural killer cell Behavioral Neuroscience Norepinephrine Internal medicine medicine Animals Sympathectomy Cytotoxicity Saline Electroshock Foot Body Weight Rats Inbred F344 Rats Killer Cells Natural Autonomic nervous system medicine.anatomical_structure Endocrinology nervous system Immunology behavior and behavior mechanisms psychological phenomena and processes Spleen medicine.drug |
| Zdroj: | Physiologybehavior. 71(3-4) |
| ISSN: | 0031-9384 |
| Popis: | We used chemical sympathectomy by 6-hydroxydopamine (6-OHDA) to examine whether adaptation by the sympathetic nervous system (SNS) is a plausible explanation for our prior finding that activity-wheel running blunts the suppression of splenic natural killer cell cytotoxicity after footshock. Male Fischer rats were assigned to treatments using a group (activity wheel vs. sedentary)x treatment (6-OHDA vs. saline)x condition (footshock vs. no shock) design. After 5-6 weeks, rats were injected i.p. with saline or with 40, 80, and 80 mg/kg 6-OHDA on pre experimental days -5, -3, and -1. Half the rats received 6 min of random footshock during a 40-min period. Cytotoxicity was determined by standard 4-h 51Cr release assay. Sympathectomy reduced splenic [NE] by 72%. After 6-OHDA injection and footshock, percent lysis was 33% lower in sedentary rats compared with activity-wheel runners and home-cage controls, p=0.048. The results suggest that activity-wheel running leads to adaptations that offset an altered SNS modulation of splenic NK cell cytotoxicity in response to footshock. |
| Databáze: | OpenAIRE |
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