Psychosocial Telephone Counseling for Survivors of Cervical Cancer: Results of a Randomized Biobehavioral Trial
| Autor: | Lari Wenzel, Jo A. Tucker, Bradley J. Monk, Kathryn Osann, Edward L. Nelson, Susie Hsieh |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Counseling Cancer Research medicine.medical_specialty Uterine Cervical Neoplasms Anxiety White People law.invention Th2 Cells Quality of life Randomized controlled trial Telephone counseling law Internal medicine Statistical significance Surveys and Questionnaires Adaptation Psychological medicine Humans Survivors Cervical cancer business.industry Depression Obstetrics and Gynecology Repeated measures design Social Support General Medicine ORIGINAL REPORTS Hispanic or Latino Middle Aged medicine.disease humanities Telephone Mood Treatment Outcome Oncology Physical therapy Quality of Life Cytokines Female medicine.symptom business Psychosocial Stress Psychological Follow-Up Studies |
| Zdroj: | Wenzel, L; Osann, K; Hsieh, S; Tucker, JA; Monk, BJ; & Nelson, EL. (2015). Psychosocial Telephone Counseling for Survivors of Cervical Cancer: Results of a Randomized Biobehavioral Trial. Obstetrical and Gynecological Survey, 70(12), 755-757. doi: 10.1097/01.ogx.0000473471.32349.65. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/79r5s6tb Wenzel, L; Osann, K; Hsieh, S; Tucker, JA; Monk, BJ; & Nelson, EL. (2015). Psychosocial telephone counseling for survivors of cervical cancer: Results of a randomized biobehavioral trial. Journal of Clinical Oncology, 33(10), 1171-1179. doi: 10.1200/JCO.2014.57.4079. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1nk0q1zg |
| DOI: | 10.1097/01.ogx.0000473471.32349.65. |
| Popis: | Purpose Survivors of cervical cancer experience quality-of-life (QOL) disruptions that persist years after treatment. This study examines the effect of a psychosocial telephone counseling (PTC) intervention on QOL domains and associations with biomarkers. Patients and Methods We conducted a randomized clinical trial in survivors of cervical cancer, who were ≥ 9 and less than 30 months from diagnosis (n = 204), to compare PTC to usual care (UC). PTC included five weekly sessions and a 1-month booster. Patient-reported outcomes (PROs) and biospecimens were collected at baseline and 4 and 9 months after enrollment. Changes in PROs over time and associations with longitudinal change in cytokines as categorical variables were analyzed using multivariable analysis of variance for repeated measures. Results Participant mean age was 43 years; 40% of women were Hispanic, and 51% were non-Hispanic white. Adjusting for age and baseline scores, participants receiving PTC had significantly improved depression and improved gynecologic and cancer-specific concerns at 4 months compared with UC participants (all P < .05); significant differences in gynecologic and cancer-specific concerns (P < .05) were sustained at 9 months. Longitudinal change in overall QOL and anxiety did not reach statistical significance. Participants with decreasing interleukin (IL) -4, IL-5, IL-10, and IL-13 had significantly greater improvement in QOL than those with increasing cytokine levels. Conclusion This trial confirms that PTC benefits mood and QOL cancer-specific and gynecologic concerns for a multiethnic underserved population of survivors of cancer. The improvement in PROs with decreases in T-helper type 2 and counter-regulatory cytokines supports a potential biobehavioral pathway relevant to cancer survivorship. |
| Databáze: | OpenAIRE |
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