Ascertainment of Silent Myocardial Infarction in Patients Undergoing Percutaneous Coronary Intervention (from the GLOBAL LEADERS Trial)

Autor: Pascal Vranckx, Yoshinobu Onuma, Olivier F. Bertrand, Tian Hai Koh, Robert-Jan van Geuns, Rodrigo Modolo, Osama Ibrahim Ibrahim Soliman, Rui Cruz Ferreira, Chun Chin Chang, Aris Moschovitis, Marco Valgimigli, Sing-Chien Yap, Stephen P. Hoole, Hidenori Komiyama, Christian W. Hamm, Amanda G. M. R. Sousa, Azfar Zaman, Philippe Gabriel Steg, Patrick W. Serruys, Tommaso Gori, Peter Jüni, Ernest Spitzer, Kuniaki Takahashi, Bernhard Frey, Stephan Windecker, Mariusz Tomaniak, Ply Chichareon, Norihiro Kogame
Přispěvatelé: Graduate School, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, ACS - Heart failure & arrhythmias, Cardiology
Rok vydání: 2019
Předmět:
Male
Ticagrelor
Internationality
medicine.medical_treatment
Myocardial Infarction
Kaplan-Meier Estimate
030204 cardiovascular system & hematology
Coronary Angiography
HSM CAR
Aspirin / therapeutic use
law.invention
Electrocardiography
0302 clinical medicine
Randomized controlled trial
law
Silent Myocardial Infarction
Clinical endpoint
Electrocardiography / methods
Prospective Studies
030212 general & internal medicine
Myocardial infarction
610 Medicine & health
education.field_of_study
Myocardial Infarction / diagnostic imaging
Drug-Eluting Stents
Middle Aged
Prognosis
Treatment Outcome
Cardiology
Drug Therapy
Combination
Female
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Population
Myocardial Infarction / mortality
Risk Assessment
Statistics
Nonparametric
03 medical and health sciences
Percutaneous Coronary Intervention
Multicenter trial
Internal medicine
medicine
Humans
Percutaneous Coronary Intervention / mortality
cardiovascular diseases
Ticagrelor / therapeutic use
education
Coronary Angiography / methods
Aged
Asymptomatic Diseases / mortality
Analysis of Variance
Aspirin
business.industry
Percutaneous coronary intervention
medicine.disease
Survival Analysis
Percutaneous Coronary Intervention / methods
Asymptomatic Diseases
Conventional PCI
Myocardial Infarction / therapy
business
Zdroj: American journal of cardiology, 124(12), 1833-1840. Elsevier Inc.
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
American Journal of Cardiology, 124(12), 1833-1840. Elsevier Inc.
ISSN: 1879-1913
0002-9149
Popis: Q-wave myocardial infarction (QWMI) comprises 2 entities. First, a clinically evident MI, which can occur spontaneously or be related to a coronary procedure. Second, silent MI which is incidentally detected on serial electrocardiographic (ECG) assessment. The prevalence of silent MI after percutaneous coronary intervention (PCI) in the drug-eluting stent era has not been fully investigated. The GLOBAL LEADERS is an all-comers multicenter trial which randomized 15,991 patients who underwent PCI to 2 antiplatelet treatment strategies. The primary end point was a composite of all-cause death or nonfatal new QWMI at 2-years follow-up. ECGs were collected at discharge, 3-month and 2-year visits, and analyzed by an independent ECG core laboratory following the Minnesota code. All new QWMI were further reviewed by a blinded independent cardiologist to identify a potential clinical correlate by reviewing clinical information. Of 15,968 participants, ECG information was complete in 14,829 (92.9%) at 2 years. A new QWMI was confirmed in 186 (1.16%) patients. Transient new Q-waves were observed in 28.5% (53 of 186) of them during the follow-up. The majority of new QWMI (78%, 146 of 186) were classified as silent MI due to the absence of a clinical correlate. Silent MI accounted for 22.1% (146 of 660) of all MI events. The prevalence of silent MI did not differ significantly between treatment strategies (experimental vs reference: 0.88% vs 0.98%, p = 0.5027). In conclusion, we document the prevalence of silent MI in an all-comers population undergoing PCI in this large-scale randomized trial. info:eu-repo/semantics/publishedVersion
Databáze: OpenAIRE
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