Effect of Disease Severity and Optic Disc Size on Diagnostic Accuracy of RTVue Spectral Domain Optical Coherence Tomograph in Glaucoma
| Autor: | Linda M. Zangwill, Felipe A. Medeiros, Luciana M. Alencar, Harsha L. Rao, Pamela A. Sample, Mauro T. Leite, Robert N. Weinreb |
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| Přispěvatelé: | Univ Calif San Diego, LV Prasad Eye Inst, Universidade Federal de São Paulo (UNIFESP), Universidade de São Paulo (USP) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Retinal Ganglion Cells
Intraocular pressure medicine.medical_specialty genetic structures Optic Disk Nerve fiber layer Optic disk Glaucoma macromolecular substances Sensitivity and Specificity Severity of Illness Index Tonometry Ocular Nerve Fibers Optical coherence tomography Ophthalmology Optic Nerve Diseases medicine Humans Intraocular Pressure Aged medicine.diagnostic_test business.industry Reproducibility of Results Articles Middle Aged medicine.disease eye diseases Scanning laser ophthalmoscopy medicine.anatomical_structure nervous system ROC Curve Area Under Curve Optic nerve sense organs Tomography business Tomography Optical Coherence |
| Zdroj: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| ISSN: | 1290-1296 |
| Popis: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Alcon Laboratories Inc. Allergan Pfizer Inc. SANTEN Inc. PURPOSE. To evaluate the effect of disease severity and optic disc size on the diagnostic accuracies of optic nerve head (ONH), retinal nerve fiber layer (RNFL), and macular parameters with RTVue (Optovue, Fremont, CA) spectral domain optical coherence tomography (SDOCT) in glaucoma.METHODS. 110 eyes of 62 normal subjects and 193 eyes of 136 glaucoma patients from the Diagnostic Innovations in Glaucoma Study underwent ONH, RNFL, and macular imaging with RTVue. Severity of glaucoma was based on visual field index (VFI) values from standard automated perimetry. Optic disc size was based on disc area measurement using the Heidelberg Retina Tomograph II (Heidelberg Engineering, Dossenheim, Germany). Influence of disease severity and disc size on the diagnostic accuracy of RTVue was evaluated by receiver operating characteristic (ROC) and logistic regression models.RESULTS. Areas under ROC curve (AUC) of all scanning areas increased (P < 0.05) as disease severity increased. for a VFI value of 99%, indicating early damage, AUCs for rim area, average RNLI thickness, and ganglion cell complex-root mean square were 0.693, 0.799, and 0.779, respectively. for a VFI of 70%, indicating severe damage, corresponding AUCs were 0.828, 0.985, and 0.992, respectively. Optic disc size did not influence the AUCs of any of the SDOCT scanning protocols of RTVue (P > 0.05). Sensitivity of the rim area increased and specificity decreased in large optic discs.CONCLUSIONS. Diagnostic accuracies of RTVue scanning protocols for glaucoma were significantly influenced by disease severity. Sensitivity of the rim area increased in large optic discs at the expense of specificity. (Invest Ophthalmol Vis Sci. 2011;92:1290-1296) DOI:10.1167/iovs.10-5516 Univ Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USA LV Prasad Eye Inst, Hyderabad, Andhra Pradesh, India Universidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil Univ São Paulo, Dept Ophthalmol, São Paulo, Brazil Universidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil CAPES: BEX1327/09-7 CAPES: NEI EY08208 CAPES: NEI EY11008 Web of Science |
| Databáze: | OpenAIRE |
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