Deoxycorticosterone-induced alkalosis in dogs
| Autor: | Daniel G. Roth, James L. Gamble |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
medicine.medical_specialty
Alkalosis Normal diet Potassium Bicarbonate Sodium Metabolic alkalosis chemistry.chemical_element Toxicology chemistry.chemical_compound Dogs Physiology (medical) Internal medicine medicine Desoxycorticosterone Pharmacology Research Sodium Dietary Liter Diet Sodium-Restricted medicine.disease Diet Endocrinology chemistry Hormone |
| Zdroj: | American Journal of Physiology-Legacy Content. 208:90-93 |
| ISSN: | 0002-9513 |
| Popis: | Metabolic alkalosis was produced with daily injections of deoxycorticosterone acetate (DCA) in eight dogs subsisting on diets deficient in potassium. In every case recovery from alkalosis was obtained within 5 days after discontinuing the hormone and without resupplying potassium. Diets low in potassium and high in sodium did not produce alkalosis without administration of the hormone nor did such diets prevent recovery from alkalosis after withdrawal of the hormone. Variations in the intake of sodium and potassium did, however, serve to modify the severity of DCA-induced alkalosis. In a study using four dogs, the increments in concentrations of bicarbonate in the plasma amounted to 2.6–3.7 mEq/liter when the animals were eating a normal diet, 5.7–10.4 when on a diet low in potassium, and 0.4–2.4 mEq/liter when both sodium and potassium were restricted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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